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Generic name: clobetasol propionate
Dosage form: topical lotion
Drug class: Topical steroids

Medically reviewed by Judith Stewart, BPharm. Last updated on Sep 21, 2023.

What is Impeklo lotion?

Impeklo lotion is a prescription corticosteroid medicine used on the skin (topical) for the relief of swelling (inflammation) and itching caused by certain skin conditions in people 18 years of age and older.

Impeklo lotion should not be used for the treatment of acne vulgaris, rosacea or red, dry itchy skin (dermatitis) around the mouth.

Impeklo lotion is not recommended in children under 18 years of age.

Important: Impeklo lotion is for use on the skin only. Do not get the lotion near or in your eyes, mouth or vagina.

Before using Impeklo lotion

Before you start treatment, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the medicines you take, including prescription or over-the-counter medicines, vitamins, and herbal supplements. Do not use other products containing corticosteroid medicine during treatment without talking to your healthcare provider first.

How should I use Impeklo lotion?

See the Instructions for Use for detailed information about the right way to apply the lotion.

Impeklo side effects

Impeklo lotion may cause serious side effects, including:

The most common side effects include thinning of the skin (atrophy), widening of small veins in the skin, skin discomfort and skin dryness.

These are not all of the possible side effects.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store Impeklo lotion?

General information about the safe and effective use of Impeklo lotion.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Impeklo lotion for a condition for which it was not prescribed. Do not give Impeklo lotion to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about Impeklo lotion that is written for health professionals.

What are the ingredients in Impeklo lotion?

Active ingredient: clobetasol propionate
Inactive ingredients: carbomer 1342, hypromellose, mineral oil, PEG-6 isostearate, propylene glycol, purified water and sodium hydroxide.


Step 1: Priming the Impeklo lotion pump (do this step only 1 time for each bottle).

Step 2: Applying Impeklo lotion to your skin.

Step 3: After using Impeklo lotion

Popular FAQ

Clobetasol can stimulate hair growth. Regrowth may be noticed as early as six weeks into treatment but may take up to 12 to 14 weeks to occur. In some people, hair regrowth does not persist long-term. Clobetasol should only be used for hair loss associated with inflammatory conditions of the scalp such as alopecia areata, scarring alopecia, psoriasis, eczema, or dermatitis. Hair loss or hair thinning may also occur, but this is a very rare side effect and is estimated to occur in only 1 out of every 300 people who use clobetasol. Clobetasol is a potent topical steroid and is not a good option for hair and scalp conditions that are not associated with inflammation. Continue reading

Clobetasol is effective at stimulating hair growth. Research has shown hair regrowth was stimulated in about 20 to 25% of people who used clobetasol ointment and in about 47% of people who used clobetasol foam. Regrowth was noticed as early as six weeks into treatment but may take up to 12 to 14 weeks to develop. Continue reading

It takes about one to three days for clobetasol propionate to start working when it is being used to treat eczema. Some improvement in symptoms such as inflammation (redness) and itching, should be noticed within this time. Other symptoms, such as dryness, crusting, or scaling may take a bit longer to resolve, but improvement should occur within a week. Continue reading

Topical clobetasol (Clobex, Impoyz, generics) is considered a very high potency topical corticosteroid (“steroid”) used on the skin, while triamcinolone (Kenalog, Triderm, generics) is a medium-to-low potency medicine. These prescription products may be used to treat conditions such as eczema, dermatitis, psoriasis, skin allergies or rashes or serious insect bites. Continue reading

Halobetasol and clobetasol are both classified as super high-potency or high-potency topical corticosteroid (“steroid”) creams used on the skin. They are both FDA-approved to treat plaque psoriasis and skin conditions that are responsive to topical corticosteroids, such as dermatitis and eczema (atopic dermatitis). They lessen skin redness and pain, itching, dryness and scaling. Continue reading

Clobetasol should not be used to treat toenail fungus, but it may be used to treat toenail psoriasis, which can resemble toenail fungus. Around 30% of people with nail psoriasis also have a fungal nail infection. Using clobetasol alone to treat toenail fungus may cause the toenail fungus to worsen and spread to other nails. Continue reading

Clobetasone propionate may be used to treat poison ivy rash if it has not yet blistered, or the rash is confined to a small area and oral corticosteroids are contraindicated. Clobetasone propionate is a super potent topical corticosteroid cream that is only approved for adults and children over the age of 12. Treatment should not exceed two weeks and no more than 50g of clobetasol propionate should be used over one week. Continue reading

It is unknown how long clobetasol stays in your system because the half-life of the drug is not available through any reference source. Some researchers have found that suppression of cortisol levels is still apparent 96 hours after topical use of this medicine, which implies that clobetasol can stay in your system for long periods of time, possibly for up to a few weeks. Clobetasol is not recommended to be used for more than two consecutive weeks. Continue reading

Impoyz (clobetasol) topical cream is typically applied as a thin layer to the affected skin areas 2 times each day. Rub the cream in gently and completely. Ask your doctor how much cream to use, where to apply it, and for how long. Always use Impoyz cream exactly as your doctor tells you to use it. Continue reading

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.