Venlafaxine and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with venlafaxine.
Venlafaxine Food
Moderate Food Interaction
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References
- Warrington SJ, Ankier SI, Turner P (1986) "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology, 15, p. 31-7
- Gilman AG, eds., Nies AS, Rall TW, Taylor P (1990) "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc.
- (2012) "Product Information. Fycompa (perampanel)." Eisai Inc
- (2015) "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc
Venlafaxine High Blood Pressure (Hypertension)
Moderate Potential Hazard, Moderate plausibility
SNRI antidepressants - hypertension
Selective serotonin and norepinephrine reuptake inhibitor antidepressants (SNRIs) have been associated with sustained increases in blood pressure. Therapy with SNRI antidepressants should be administered cautiously in patients with preexisting hypertension. Blood pressure should be assessed prior to initiating treatment and monitored regularly. The dose should be reduced or discontinued if necessary.
References
- (2001) "Product Information. Effexor (venlafaxine)." Wyeth-Ayerst Laboratories
- (2004) "Product Information. Cymbalta (duloxetine)." Lilly, Eli and Company
- (2008) "Product Information. Pristiq (desvenlafaxine)." Wyeth Laboratories
- (2009) "Product Information. Savella (milnacipran)." Forest Pharmaceuticals
- (2013) "Product Information. Fetzima (levomilnacipran)." Forest Pharmaceuticals
Venlafaxine drug interactions
There are 693 drug interactions with venlafaxine.
Venlafaxine disease interactions
There are 11 disease interactions with venlafaxine which include:
- depression
- renal disease
- renal/liver disease
- mania
- glaucoma
- hypertension
- hyponatremia
- mania
- seizures
- urinary tract obstruction
- weight loss
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.