Temsirolimus and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with temsirolimus.
Temsirolimus Food
Moderate Food Interaction
GENERALLY AVOID: Coadministration of temsirolimus with grapefruit juice may increase the plasma concentrations of sirolimus, a major active metabolite of temsirolimus and known substrate of CYP450 3A4. The proposed mechanism is inhibition of CYP450 3A4-mediated metabolism by certain compounds present in grapefruits.
MANAGEMENT: Patients treated with temsirolimus should preferably avoid the consumption of grapefruit or grapefruit juice.
References (1)
- (2007) "Product Information. Torisel (temsirolimus)." Wyeth-Ayerst Laboratories
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Temsirolimus High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Moderate Potential Hazard, Moderate plausibility
mTOR inhibitors - cholesterol
Elevations in cholesterol and triglyceride levels have been reported in patients taking inhibitors of mTOR (mammalian target of rapamycin). Monitoring of fasting lipid profile is recommended prior to the start of therapy and periodically thereafter. Clinicians should achieve control of lipid levels before initiating therapy with these agents.
References (2)
- (2007) "Product Information. Torisel (temsirolimus)." Wyeth-Ayerst Laboratories
- (2009) "Product Information. Afinitor (everolimus)." Novartis Pharmaceuticals
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Temsirolimus drug interactions
There are 700 drug interactions with temsirolimus.
Temsirolimus disease interactions
There are 10 disease interactions with temsirolimus which include:
- vaccination
- renal disease
- GI perforation
- hypersensitivity
- liver disease
- blood glucose
- cholesterol
- Infections
- wound complication
- lung dysfunction
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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