Simeprevir and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with simeprevir.
Simeprevir Food
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food significantly enhances the oral bioavailability of simeprevir, although the type of food does not seem to matter. In healthy study subjects, administration of simeprevir after a high-fat, high-caloric (928 kcal) breakfast increased systemic exposure (AUC) by 61% and delayed absorption by 1 hour, while administration after a normal caloric (533 kcal) breakfast increased AUC by 69% and delayed absorption by 1.5 hours.
MANAGEMENT: To ensure maximal oral absorption, simeprevir should be administered with food.
References (1)
- (2013) "Product Information. Olysio (simeprevir)." Janssen Pharmaceuticals
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Simeprevir drug interactions
There are 198 drug interactions with simeprevir.
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- During pregnancy
- Drug class: protease inhibitors
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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