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Simeprevir Dosage

Applies to the following strengths: 150 mg

Usual Adult Dose for Chronic Hepatitis C

150 mg orally once a day with food

Recommended Regimen and Duration of Therapy:
Therapy-naive and therapy-experienced patients with HCV genotype 1 infection:

Therapy-naive patients and prior relapsers with HCV genotype 1 or 4 infection:

Prior non-responders (including partial and null responders) with HCV genotype 1 or 4 infection:

Treatment Stopping Rules for Patients with Inadequate On-Treatment Virologic Response during Treatment with Simeprevir, Peginterferon alfa, and Ribavirin:


Use: For the treatment of chronic HCV infection

Renal Dose Adjustments

Mild, moderate, or severe renal dysfunction: No adjustment recommended.


Liver Dose Adjustments

Mild liver dysfunction (Child-Pugh A): No adjustment recommended.
Moderate or severe liver dysfunction (Child-Pugh B or C): Not recommended.


Dose Adjustments

To prevent treatment failure, reducing the dose of this drug or interrupting treatment should be avoided. If this drug is stopped due to side effects or inadequate on-treatment virologic response, it must not be restarted.

The manufacturer product information for coadministered HCV antiviral drugs should be consulted for appropriate dose adjustment or interruption due to side effects. If any of the coadministered HCV antiviral drugs are permanently stopped for any reason, this drug should also be discontinued.



Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available


Other Comments

Administration advice:

Storage requirements:



Patient advice:

Frequently asked questions

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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.