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Adempas and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with Adempas (riociguat).


Riociguat Food

Moderate Food Interaction

Chemical substances present in cigarette smoke may reduce the blood levels of riociguat. This means that the medication may be less effective if you smoke during treatment. Let your doctor know if you are a smoker, or if you start smoking or stop smoking during treatment with riociguat, because the dosage may need to be adjusted. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Riociguat High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

riociguat - hypotension

Riociguat reduces blood pressure. There is a potential for symptomatic hypotension or ischemia in patients with hypovolemia, severe left ventricular outflow obstruction, resting hypotension, autonomic dysfunction, or concomitant treatment with antihypertensive agents. Caution is advised when using riociguat in these patients.


  1. (2013) "Product Information. Adempas (riociguat)." Bayer Pharmaceutical Inc

Adempas drug interactions

There are 284 drug interactions with Adempas (riociguat).

Adempas disease interactions

There are 3 disease interactions with Adempas (riociguat) which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.