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Nexcede (ketoprofen) and Alcohol / Food Interactions

There are 3 alcohol/food/lifestyle interactions with Nexcede (ketoprofen) which include:


ketoprofen ↔ Alcohol (Ethanol)

Moderate Drug Interaction

Ask your doctor before using ketoprofen together with ethanol. Do not drink alcohol while taking ketoprofen. Alcohol can increase your risk of stomach bleeding caused by ketoprofen. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data


High Blood Pressure (Hypertension)

Severe Potential Hazard, Moderate plausibility

NSAIDs - fluid retention

Fluid retention and edema have been reported in association with the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Therapy with NSAIDs should be administered cautiously in patients with preexisting fluid retention, hypertension, or a history of heart failure. Blood pressure and cardiovascular status should be monitored closely during the initiation of NSAID treatment and throughout the course of therapy.


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  3. "Product Information. Daypro (oxaprozin)." Searle, Skokie, IL.
  4. "Product Information. Orudis (ketoprofen)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
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  6. "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
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  8. "Product Information. Nalfon (fenoprofen)." Xspire Pharma, Ridgeland, MS.
  9. "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc, Palo Alto, CA.
  10. "Product Information. Celebrex (celecoxib)." Searle, Chicago, IL.
  11. "Product Information. Anaprox (naproxen)." Roche Laboratories, Nutley, NJ.
  12. "Product Information. Mobic (meloxicam)" Boehringer-Ingelheim, Ridgefield, CT.
  13. "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn, Kalamazoo, MI.
  14. Heynen G "Toleration and safety of piroxicam." Eur J Rheumatol Inflamm 8 (1987): 86-93
  15. "Product Information. Feldene (piroxicam)." Pfizer US Pharmaceuticals, New York, NY.
  16. "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn, Kalamazoo, MI.
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  20. "Product Information. Vioxx (rofecoxib)." Merck & Co, Inc, West Point, PA.
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  22. "Product Information. Indocin (indomethacin)." Merck & Co, Inc, West Point, PA.
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  24. Petersson I, Nilsson G, Hansson B-G, Hedner T "Water intoxication associated with non-steroidal anti-inflammatory drug therapy." Acta Med Scand 221 (1987): 221-3
  25. "Product Information. Tolectin (tolmetin)." McNeil Pharmaceutical, Raritan, NJ.
  26. "Product Information. Relafen (nabumetone)." SmithKline Beecham, Philadelphia, PA.
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  29. "Product Information. Bextra (valdecoxib)." Pharmacia Corporation, Peapack, NJ.
View all 29 references

High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

NSAIDs - hypertension

NSAIDs including topicals can lead to the onset of new hypertension or worsening of preexisting hypertension, either of which can contribute to the increased incidence of cardiovascular events. Blood pressure should be monitored closely during NSAID therapy and throughout the course of therapy.

Nexcede (ketoprofen) drug Interactions

There are 414 drug interactions with Nexcede (ketoprofen)

Nexcede (ketoprofen) disease Interactions

There are 12 disease interactions with Nexcede (ketoprofen) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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