Utibron Neohaler (glycopyrrolate / indacaterol) and Alcohol / Food Interactions
There are 3 alcohol/food/lifestyle interactions with Utibron Neohaler (glycopyrrolate / indacaterol) which include:
glycopyrrolate ↔ Alcohol (Ethanol)
Moderate Drug Interaction
Ask your doctor before using glycopyrrolate together with ethanol. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking glycopyrrolate. You should be warned not to exceed recommended dosages and to avoid activities requiring mental alertness. If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
High Blood Pressure (Hypertension)
Moderate Potential Hazard, Moderate plausibility
beta- 2 adrenergic bronchodilators - cardiovascular
Adrenergic bronchodilators can stimulate cardiovascular beta- 1 and beta- 2 receptors, resulting in adverse effects such as tachycardia, palpitation, peripheral vasodilation, blood pressure changes, and ECG changes (e.g., flattening of the T wave; prolongation of the QT interval; ST segment depression). Direct stimulation of cardiac tissues is mediated by beta- 1 receptors and thus less likely to occur with beta-2-selective agents such as albuterol. However, beta-2-selectivity is not absolute and can be lost with larger doses. High dosages of these agents have been associated with precipitation or aggravation of angina, myocardial ischemia, and cardiac arrhythmias. Therapy with adrenergic bronchodilators should be administered cautiously in patients with sensitivity to sympathomimetic amines, hyperthyroidism, and/or underlying cardiovascular disorders such as coronary insufficiency, cardiac arrhythmias, or hypertension. The recommended dosages should not be exceeded.
- Tranfa CME, Pelaia G, Grembiale RD, Naty S, Durante S, Borrello G "Short-term cardiovascular effects of salmeterol." Chest 113 (1998): 1272-6
- Price AH, Clissold SP "Salbutamol in the 1980s. A reappraisal of its clinical efficacy." Drugs 38 (1989): 77-122
- Maguire GP, Emirgil C "Bronchodilator and side effects of different modes of administration of metaproterenol: inhaled, oral, and in combination." Am J Med Sci 291 (1986): 168-74
High Blood Pressure (Hypertension)
Minor Potential Hazard, Moderate plausibility
anticholinergics - hypertension
Cardiovascular effects of anticholinergics may exacerbate hypertension. Therapy with anticholinergic agents should be administered cautiously in patients with hypertension.
- "Product Information. Marezine (cyclizine)." Glaxo Wellcome, Research Triangle Park, NC.
- "Product Information. Benadryl (diphenhydramine)." Parke-Davis, Morris Plains, NJ.
- "Product Information. Cogentin (benztropine)." Merck & Co, Inc, West Point, PA.
Utibron Neohaler (glycopyrrolate / indacaterol) drug Interactions
There are 1024 drug interactions with Utibron Neohaler (glycopyrrolate / indacaterol)
Utibron Neohaler (glycopyrrolate / indacaterol) disease Interactions
There are 14 disease interactions with Utibron Neohaler (glycopyrrolate / indacaterol) which include:
- Autonomic Neuropathy
- Gi Obstruction
- Obstructive Uropathy
- Tardive Dyskinesia
- Infectious Diarrhea
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2017 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.