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Antabuse (disulfiram) and Alcohol / Food Interactions

There are 2 alcohol/food/lifestyle interactions with Antabuse (disulfiram) which include:


Caffeine ↔ disulfiram

Minor Drug Interaction

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

For clinical details see professional interaction data.


disulfiram ↔ Alcohol (Ethanol)

Major Drug Interaction

You should not drink alcoholic beverages or use medicines that contain ethanol during treatment with disulfiram. This can cause flushing, nausea and vomiting, blurred vision, shortness of breath, rapid heart beat, and low blood pressure. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor.

Switch to professional interaction data

Antabuse (disulfiram) drug interactions

There are 171 drug interactions with Antabuse (disulfiram)

Antabuse (disulfiram) disease interactions

There are 5 disease interactions with Antabuse (disulfiram) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.