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Antabuse Side Effects

Generic Name: disulfiram

Note: This page contains information about the side effects of disulfiram. Some of the dosage forms included on this document may not apply to the brand name Antabuse.

For the Consumer

Applies to disulfiram: oral tablet

In addition to its needed effects, some unwanted effects may be caused by disulfiram (the active ingredient contained in Antabuse). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking disulfiram, check with your doctor or nurse as soon as possible:

Less common:
  • Eye pain or tenderness or any change in vision
  • mood or mental changes
  • numbness, tingling, pain, or weakness in hands or feet
  • Darkening of urine
  • light gray-colored stools
  • severe stomach pain
  • yellow eyes or skin

Minor Side Effects

Some of the side effects that can occur with disulfiram may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Drowsiness
Less common or rare:
  • Decreased sexual ability in males
  • headache
  • metallic or garlic-like taste in mouth
  • skin rash
  • unusual tiredness

For Healthcare Professionals

Applies to disulfiram: oral tablet


Frequency not reported: Fatigue[Ref]


Rare (less than 0.1%): Altered liver function tests
Frequency not reported: Hepatic cell damage, hepatitis (cholestatic and fulminant), hepatic failure resulting in transplant or death, jaundice, cirrhosis[Ref]

Nervous system

Frequency not reported: Drowsiness, peripheral neuritis, encephalopathy, polyneuritis, peripheral neuropathy, headache, seizures, lethargy[Ref]


Frequency not reported: Skin eruptions, acneiform eruptions, allergic dermatitis, maculopapular rash[Ref]


Frequency not reported: Nausea, vomiting, halitosis, metallic or garlic-like aftertaste, stomach upset[Ref]


Frequency not reported: Optic neuritis, eye pain or tenderness, changes in vision[Ref]


Frequency not reported: Decreased libido[Ref]


Frequency not reported: Psychotic reactions, depression, paranoia, schizophrenia, mania, confusion, personality changes, disorientation, memory impairment[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Antabuse (disulfiram)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

3. Cerner Multum, Inc. "Australian Product Information." O 0

Not all side effects for Antabuse may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.