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Antabuse (disulfiram) Disease Interactions

There are 5 disease interactions with Antabuse (disulfiram):

Major

Disulfiram (Includes Antabuse) ↔ Alcohol Intoxication

Severe Potential Hazard, High plausibility

Applies to: Acute Alcohol Intoxication

The administration of disulfiram is contraindicated in patients in a state of alcohol intoxication. The disulfiram- alcohol reaction may produce symptoms including flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, weakness, vertigo, blurred vision, and confusion. Severe reactions may result in respiratory depression, cardiovascular collapse, arrhythmias, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death.

References

  1. "Product Information. Antabuse (disulfiram)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  2. Elenbaas RM "Drug therapy reviews: management of the disulfiram-alcohol reaction." Am J Hosp Pharm 34 (1977): 827-31
Major

Disulfiram (Includes Antabuse) ↔ Cardiac Disease

Severe Potential Hazard, High plausibility

Applies to: Cardiovascular Disease

The use of disulfiram is contraindicated in patients with cardiac disease. The potential for a disulfiram- alcohol reaction, symptoms of which can include cardiovascular effects such as palpitation, tachycardia, chest pain, hypotension, syncope and, in severe cases, cardiovascular collapse, arrhythmias, myocardial infarction, and acute congestive heart failure, may present a particular danger to these patients.

References

  1. "Product Information. Antabuse (disulfiram)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Major

Disulfiram (Includes Antabuse) ↔ Disulfiram Reaction

Severe Potential Hazard, High plausibility

Applies to: Glomerulonephritis, Seizures, Hypothyroidism, Diabetes Mellitus

The disulfiram- alcohol reaction may produce symptoms including flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, weakness, vertigo, blurred vision, and confusion. Severe reactions may result in respiratory depression, cardiovascular collapse, arrhythmias, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death. Because of the possibility of an accidental disulfiram- alcohol reaction, disulfiram should be used with extreme caution in patients with diabetes mellitus, hypothyroidism, seizure disorders, cerebral damage, chronic and acute nephritis, hepatic cirrhosis or insufficiency.

References

  1. Fernandez D "Another esophageal rupture after alcohol and disulfiram." N Engl J Med 286 (1972): 610
  2. "Product Information. Antabuse (disulfiram)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  3. Elenbaas RM "Drug therapy reviews: management of the disulfiram-alcohol reaction." Am J Hosp Pharm 34 (1977): 827-31
  4. Enghusen Poulsen H, Loft S, Andersen JR, Andersen M "Disulfiram therapy--adverse drug reactions and interactions." Acta Psychiatr Scand Suppl 369 (1992): 59-65;
View all 4 references
Major

Disulfiram (Includes Antabuse) ↔ Psychoses

Severe Potential Hazard, High plausibility

Applies to: Psychosis

The use of disulfiram is contraindicated in patients with psychosis. Disulfiram may precipitate psychotic reactions and mood disorders, particularly when given in high dosages or with metronidazole or isoniazid. In some cases, however, the sudden withdrawal of alcohol alone can unmask underlying psychotic disorders.

References

  1. Fisher CM "'Catatonia' due to disulfiram toxicity." Arch Neurol 46 (1989): 798-804
  2. Enghusen Poulsen H, Loft S, Andersen JR, Andersen M "Disulfiram therapy--adverse drug reactions and interactions." Acta Psychiatr Scand Suppl 369 (1992): 59-65;
  3. Liddon SC, Satran R "Disulfiram (Antabuse) psychosis." Am J Psychiatry 123 (1967): 1284-9
  4. "Product Information. Antabuse (disulfiram)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  5. Reisberg B "Catatonia associated with disulfiram therapy." J Nerv Ment Dis 166 (1978): 607-9
  6. Weddington WW, Jr Marks RC, Verghese JP "Disulfiram encephalopathy as a cause of the catatonia syndrome." Am J Psychiatry 137 (1980): 1217-9
View all 6 references
Moderate

Disulfiram (Includes Antabuse) ↔ Hepatotoxicity

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

Hepatic toxicity, hepatitis, and hepatic failure resulting in transplantation or death have been reported with the use of disulfiram. Hepatic toxicity has occurred in patient with and without prior history of abnormal liver function. Extreme caution and close monitoring is advised if used in patients with liver impairment. Baseline and liver tests are suggested in all patients to detect any hepatic abnormalities. Patients should be advised to immediately notify their health provider if any symptoms of hepatitis occur (weakness, fatigue, anorexia, nausea, vomiting, jaundice, or dark urine).

Antabuse (disulfiram) drug Interactions

There are 242 drug interactions with Antabuse (disulfiram)

Antabuse (disulfiram) alcohol/food Interactions

There are 2 alcohol/food interactions with Antabuse (disulfiram)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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