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Dolobid (diflunisal) and Alcohol / Food Interactions

There is 1 alcohol/food/lifestyle interaction with Dolobid (diflunisal):

Major

High Blood Pressure (Hypertension)

Severe Potential Hazard, Moderate plausibility

NSAIDs - fluid retention

Fluid retention and edema have been reported in association with the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Therapy with NSAIDs should be administered cautiously in patients with preexisting fluid retention, hypertension, or a history of heart failure. Blood pressure and cardiovascular status should be monitored closely during the initiation of NSAID treatment and throughout the course of therapy.

References

  1. Heerdink ER, Leufkens HG, Herings RM, Ottervanger JP, Stricker BH, Bakker A "NSAIDs associated with increased risk of congestive heart failure in elderly patients taking diuretics." Arch Intern Med 158 (1998): 1108-12
  2. Agnholt J, Andreasen F "The effect of ibuprofen therapy on water and electrolyte balance." Acta Med Scand 212 (1982): 65-9
  3. "Product Information. Celebrex (celecoxib)." Searle, Chicago, IL.
  4. "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  5. "Product Information. Orudis (ketoprofen)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  6. Lewis RV, Toner JM, Jackson PR, Ramsay LE "Effects of indomethacin and sulindac on blood pressure of hypertensive patients." Br Med J 292 (1986): 934-5
  7. "Product Information. Daypro (oxaprozin)." Searle, Skokie, IL.
  8. Van Den Ouweland FA, Gribnau FW, Meyboom RH "Congestive heart failure due to nonsteroidal anti-inflammatory drugs in the elderly." Age Ageing 17 (1988): 8-16
  9. Johnson AG, Nguyen TV, Day RO "Do nonsteroidal anti-inflammatory drugs affect blood pressure? A meta-analysis." Ann Intern Med 121 (1994): 289-300
  10. "Product Information. Mobic (meloxicam)" Boehringer-Ingelheim, Ridgefield, CT.
  11. "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc, Palo Alto, CA.
  12. "Product Information. Nalfon (fenoprofen)." Xspire Pharma, Ridgeland, MS.
  13. "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn, Kalamazoo, MI.
  14. "Product Information. Anaprox (naproxen)." Roche Laboratories, Nutley, NJ.
  15. Heynen G "Toleration and safety of piroxicam." Eur J Rheumatol Inflamm 8 (1987): 86-93
  16. Willkens RF "Worldwide clinical safety experience with diclofenac." Semin Arthritis Rheum 2 Suppl 1 (1985): 105-10
  17. "Product Information. Feldene (piroxicam)." Pfizer US Pharmaceuticals, New York, NY.
  18. "Product Information. Clinoril (sulindac)." Merck & Co, Inc, West Point, PA.
  19. "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn, Kalamazoo, MI.
  20. "Product Information. Indocin (indomethacin)." Merck & Co, Inc, West Point, PA.
  21. Gurwitz JH, Everitt DE, Monane M, et al "The impact of ibuprofen on the efficacy of antihypertensive treatment with hydrochlorothiazide in elderly persons." J Gerontol A Biol Sci Med Sci 51 (1996): m74-9
  22. "Product Information. Vioxx (rofecoxib)." Merck & Co, Inc, West Point, PA.
  23. Easton PA, Koval A "Hypertensive reaction with sulindac." Can Med Assoc J 122 (1980): 1273-4
  24. Brooks CD, Linet OI, Schellenberg D, Turner LF, Defesche CL, Teoh KW, Johnson JH, Assenzo JR "Clinical safety of flurbiprofen." J Clin Pharmacol 30 (1990): 342-51
  25. Petersson I, Nilsson G, Hansson B-G, Hedner T "Water intoxication associated with non-steroidal anti-inflammatory drug therapy." Acta Med Scand 221 (1987): 221-3
  26. Buckley MM, Brogden RN "Ketorolac. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential." Drugs 39 (1990): 86-109
  27. "Product Information. Tolectin (tolmetin)." McNeil Pharmaceutical, Raritan, NJ.
  28. "Product Information. Relafen (nabumetone)." SmithKline Beecham, Philadelphia, PA.
  29. "Product Information. Bextra (valdecoxib)." Pharmacia Corporation, Peapack, NJ.
View all 29 references

Dolobid (diflunisal) drug interactions

There are 560 drug interactions with Dolobid (diflunisal)

Dolobid (diflunisal) disease interactions

There are 8 disease interactions with Dolobid (diflunisal) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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