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Welchol and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with Welchol (colesevelam).


multivitamins with minerals colesevelam

Moderate Drug Interaction

Using colesevelam together with multivitamin with minerals may decrease the effects of multivitamin with minerals. Multivitamin with minerals should be administered at least 4 hours before colesevelam. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)

Major Potential Hazard, Moderate plausibility

colesevelam - TG

The manufacturer considers the use of colesevelam to be contraindicated in patients with TG levels >500 mg/dL. Colesevelam, like other bile acid sequestrants, can increase serum TG concentrations. Lipid parameters, including TG levels and non-HDL-C, should be obtained before starting colesevelam and periodically thereafter. Caution should be exercised when treating patients with TG levels greater than 300 mg/dL. Colesevelam should be discontinued if TG levels exceed 500 mg/dL or if the patient develops hypertriglyceridemia-induced pancreatitis.


  1. "Product Information. Welchol (colesevelam)." Daiichi Sankyo, Inc. (2001):

Welchol drug interactions

There are 88 drug interactions with Welchol (colesevelam).

Welchol disease interactions

There are 5 disease interactions with Welchol (colesevelam) which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.