Chlorpheniramine/ibuprofen/pseudoephedrine and Alcohol/Food Interactions
There are 3 alcohol/food/lifestyle interactions with chlorpheniramine / ibuprofen / pseudoephedrine.
chlorpheniramine food
Moderate Food Interaction
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References
- Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7
- Gilman AG, eds., Nies AS, Rall TW, Taylor P "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc. (1990):
- "Product Information. Fycompa (perampanel)." Eisai Inc (2012):
- "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc (2015):
High Blood Pressure (Hypertension)
Major Potential Hazard, Moderate plausibility
NSAIDs - fluid retention
Fluid retention and edema have been reported in association with the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Therapy with NSAIDs should be administered cautiously in patients with preexisting fluid retention, hypertension, or a history of heart failure. Blood pressure and cardiovascular status should be monitored closely during the initiation of NSAID treatment and throughout the course of therapy.
References
- "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn PROD (2002):
- "Product Information. Nalfon (fenoprofen)." Xspire Pharma PROD (2002):
- "Product Information. Indocin (indomethacin)." Merck & Co., Inc PROD (2002):
- "Product Information. Orudis (ketoprofen)." Wyeth-Ayerst Laboratories PROD (2002):
- "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc PROD (2002):
- "Product Information. Anaprox (naproxen)." Roche Laboratories PROD (2006):
- "Product Information. Clinoril (sulindac)." Merck & Co., Inc PROD (2001):
- "Product Information. Tolectin (tolmetin)." McNeil Pharmaceutical PROD (2001):
- "Product Information. Relafen (nabumetone)." SmithKline Beecham PROD (2001):
- "Product Information. Feldene (piroxicam)." Pfizer U.S. Pharmaceuticals PROD (2001):
- "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn PROD (2001):
- "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories PROD (2001):
- "Product Information. Daypro (oxaprozin)." Searle PROD (2001):
- "Product Information. Mobic (meloxicam)." Boehringer-Ingelheim PROD (2001):
High Blood Pressure (Hypertension)
Moderate Potential Hazard, Moderate plausibility
NSAIDs - hypertension
Nonsteroidal anti-inflammatory drugs (NSAIDs), including topicals, can lead to new onset of hypertension or worsening of preexisting hypertension, either of which can contribute to the increased incidence of cardiovascular events. NSAIDs should be used with caution in patients with hypertension. Blood pressure should be monitored closely during the initiation of NSAID therapy and throughout the course of therapy.
References
- "Product Information. Indocin (indomethacin)." Merck & Co., Inc PROD (2002):
- "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc PROD (2002):
- "Product Information. Voltaren (diclofenac)." Novartis Pharmaceuticals PROD (2001):
- "Product Information. Relafen (nabumetone)." SmithKline Beecham PROD (2001):
- "Product Information. Feldene (piroxicam)." Pfizer U.S. Pharmaceuticals PROD (2001):
- "Product Information. Dolobid (diflunisal)." Merck & Co., Inc PROD (2001):
- "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn PROD (2001):
- "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories PROD (2001):
- "Product Information. Daypro (oxaprozin)." Searle PROD (2001):
- "Product Information. Celebrex (celecoxib)." Searle PROD (2001):
- "Product Information. Meclofenamate Sodium (meclofenamate)." Mylan Pharmaceuticals Inc (2012):
- "Product Information. Flector Patch (diclofenac topical)." Actavis U.S. (Alpharma USPD) (2016):
Chlorpheniramine/ibuprofen/pseudoephedrine drug interactions
There are 824 drug interactions with chlorpheniramine / ibuprofen / pseudoephedrine.
Chlorpheniramine/ibuprofen/pseudoephedrine disease interactions
There are 23 disease interactions with chlorpheniramine / ibuprofen / pseudoephedrine which include:
- asthma
- fluid retention
- GI toxicity
- rash
- renal toxicities
- thrombosis
- cardiovascular disease
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- PKU
- anemia
- heart failure
- hepatotoxicity
- hyperkalemia
- hypertension
- platelet aggregation inhibition
- GI narrowing
- PKU
- BPH
- diabetes
- glaucoma
More about chlorpheniramine / ibuprofen / pseudoephedrine
- chlorpheniramine/ibuprofen/pseudoephedrine consumer information
- Check interactions
- Compare alternatives
- Side effects
- Dosage information
- Drug class: upper respiratory combinations
- En español
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.