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Principen (ampicillin) and Alcohol / Food Interactions

There are 2 alcohol/food/lifestyle interactions with Principen (ampicillin) which include:

Moderate

ampicillin ↔ food

Moderate Food Interaction

You may experience reduced absorption of ampicillin in the presence of food. The effectiveness of the antibiotic may be reduced. Ampicillin should be administered one hour before or two hours after meals. This will make it easier for your body to absorb the medication. Penicillin V and amoxicillin are not affected by food and may be given without regard to meals.

Switch to professional interaction data

Moderate

High Blood Pressure (Hypertension)

Moderate Potential Hazard, High plausibility

ampicillin - sodium

Parenteral ampicillin sodium contains approximately 67 to 71 mg (2.9 to 3.1 mEq) of sodium per each gram of ampicilliin activity. The combination, ampicillin-sulbactam, contains approximately 115 mg (5 mEq) of sodium per 1.5 gram of total drug. The sodium content should be considered when these products are used in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.

References

  1. "Product Information. Unasyn (ampicillin-sulbactam)." Roerig Division, New York, NY.
  2. "Product Information. Omnipen (ampicillin)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

Principen (ampicillin) drug Interactions

There are 69 drug interactions with Principen (ampicillin)

Principen (ampicillin) disease Interactions

There are 5 disease interactions with Principen (ampicillin) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2016 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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