Limbitrol (amitriptyline / chlordiazepoxide) and Alcohol / Food Interactions
There are 2 alcohol/food/lifestyle interactions with Limbitrol (amitriptyline / chlordiazepoxide) which include:
chlordiazePOXIDE ↔ food
Moderate Food Interaction
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References
- Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):
- "Product Information. Fycompa (perampanel)." Eisai Inc, Teaneck, NJ.
- Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7
Obesity
Moderate Potential Hazard, Moderate plausibility
benzodiazepines - obesity
The plasma half-lives of benzodiazepines may be prolonged in obese patients, presumably due to increased distribution into fat. Marked increases in distribution (> 100%) have been reported for diazepam and midazolam, and moderate increases (25% to 100%) for alprazolam, lorazepam, and oxazepam. Therapy with benzodiazepines should be administered cautiously in obese patients, with careful monitoring of CNS status. Longer dosing intervals may be appropriate. When dosing by weight, loading doses should be based on actual body weight, while maintenance dose should be based on ideal body weight to avoid toxicity.
References
- "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical, Abbott Park, IL.
- "Product Information. Librium (chlordiazepoxide)." Roche Laboratories, Nutley, NJ.
- "Product Information. Ativan (lorazepam)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Limbitrol (amitriptyline / chlordiazepoxide) drug Interactions
There are 1209 drug interactions with Limbitrol (amitriptyline / chlordiazepoxide)
Limbitrol (amitriptyline / chlordiazepoxide) disease Interactions
There are 33 disease interactions with Limbitrol (amitriptyline / chlordiazepoxide) which include:
- Acute Alcohol Intoxication
- Closed-Angle Glaucoma
- Drug Dependence
- Renal/Liver Disease
- Respiratory Depression
- Seizures
- Prolonged Hypotension
- Anticholinergic Effects
- Cardiovascular Disease
- Pheochromocytoma
- Seizure Disorders
- Acute Myocardial Infarction Recovery
- Cardiovascular Disease
- Depression
- Seizure Disorders
- Depression
- Obesity
- Paradoxical Reactions
- Porphyria
- Bone Marrow Suppression
- Diabetes
- Renal/Liver Disease
- Schizophrenia/Bipolar Disorder
- Tardive Dyskinesia
- Acute Alcohol Intoxication
- Bipolar Disorder Screening
- Glaucoma
- Hyper/Hypoglycemia
- Liver/Renal Disease
- Neutropenia
- Schizophrenia
- Thyroid Disorders
- Urinary Retention
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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