Limbitrol (amitriptyline / chlordiazepoxide) and Alcohol / Food Interactions
There are 2 alcohol/food/lifestyle interactions with Limbitrol (amitriptyline / chlordiazepoxide) which include:
chlordiazePOXIDE ↔ food
Moderate Food Interaction
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References
- Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7
- Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):
- "Product Information. Fycompa (perampanel)." Eisai Inc, Teaneck, NJ.
- "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc, Rockville, MD.
Obesity
Moderate Potential Hazard, Moderate plausibility
benzodiazepines - obesity
The plasma half-lives of benzodiazepines may be prolonged in obese patients, presumably due to increased distribution into fat. Marked increases in distribution (> 100%) have been reported for diazepam and midazolam, and moderate increases (25% to 100%) for alprazolam, lorazepam, and oxazepam. Therapy with benzodiazepines should be administered cautiously in obese patients, with careful monitoring of CNS status. Longer dosing intervals may be appropriate. When dosing by weight, loading doses should be based on actual body weight, while maintenance dose should be based on ideal body weight to avoid toxicity.
References
- "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical, Abbott Park, IL.
- "Product Information. Librium (chlordiazepoxide)." Roche Laboratories, Nutley, NJ.
- "Product Information. Serax (oxazepam)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- "Product Information. Ativan (lorazepam)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- "Product Information. Halcion (triazolam)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Klonopin (clonazepam)." Roche Laboratories, Nutley, NJ.
- "Product Information. Restoril (temazepam)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
- "Product Information. ProSom (estazolam)." Abbott Pharmaceutical, Abbott Park, IL.
- "Product Information. Valium (diazepam)." Roche Laboratories, Nutley, NJ.
- "Product Information. Xanax (alprazolam)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Versed (midazolam)." Roche Laboratories, Nutley, NJ.
- "Product Information. Doral (quazepam)." Wallace Laboratories, Cranbury, NJ.
- "Product Information. Dalmane (flurazepam)." Roche Laboratories, Nutley, NJ.
- American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
Limbitrol (amitriptyline / chlordiazepoxide) drug Interactions
There are 1244 drug interactions with Limbitrol (amitriptyline / chlordiazepoxide)
Limbitrol (amitriptyline / chlordiazepoxide) disease Interactions
There are 32 disease interactions with Limbitrol (amitriptyline / chlordiazepoxide) which include:
- Acute Alcohol Intoxication
- Closed-Angle Glaucoma
- Drug Dependence
- Renal/Liver Disease
- Respiratory Depression
- Seizures
- Prolonged Hypotension
- Anticholinergic Effects
- Cardiovascular Disease
- Pheochromocytoma
- Acute Myocardial Infarction Recovery
- Cardiovascular Disease
- Depression
- Seizure Disorders
- Depression
- Obesity
- Paradoxical Reactions
- Porphyria
- Bone Marrow Suppression
- Diabetes
- Renal/Liver Disease
- Schizophrenia/Bipolar Disorder
- Tardive Dyskinesia
- Acute Alcohol Intoxication
- Bipolar Disorder Screening
- Glaucoma
- Hyper/Hypoglycemia
- Liver/Renal Disease
- Neutropenia
- Schizophrenia
- Thyroid Disorders
- Urinary Retention
See Also
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No information available. |
Do not stop taking any medications without consulting your healthcare provider.
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2018 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
