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Tramadol Hydrochloride ER (tramadol) Drug Interactions

A total of 944 drugs are known to interact with Tramadol Hydrochloride ER (tramadol).

  • 491 major drug interactions
  • 445 moderate drug interactions
  • 8 minor drug interactions

Show all medications in the database that may interact with Tramadol Hydrochloride ER (tramadol).

Check for interactions with Tramadol Hydrochloride ER (tramadol)

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Common medications checked in combination with Tramadol Hydrochloride ER (tramadol)

  • amlodipine (Norvasc)
  • atorvastatin (Lipitor)
  • cyclobenzaprine (Flexeril, Amrix, Fexmid, Comfort Pac with Cyclobenzaprine)
  • furosemide (Lasix, Diaqua-2, Lo-Aqua)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • ibuprofen (Advil, Motrin, IBU, Proprinal, Advil Liqui-Gels, Motrin IB, IBU-200, Nuprin, Advil Infant's Concentrated Drops, Children's Motrin, Advil Children's, Ibu-8, Ibuprofen PMR, Caldolor, Motrin Childrens, Motrin Migraine Pain, Addaprin, Ibu-4, Ibu-Tab, Rufen, Midol IB, A-G Profen, Childrens Ibuprofen Berry, Advil Migraine, Ibu-6, Motrin Infant Drops, NeoProfen, Genpril, Haltran, Menadol, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Levothyrox, Unithroid, Euthyrox, Levo-T, L Thyroxine Roche, Novothyrox, Levotabs, Oroxine, Eutroxsig, Tirosint-Sol, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • losartan (Cozaar)
  • Lyrica (pregabalin)
  • meloxicam (Mobic, Vivlodex, Qmiiz ODT)
  • metformin (Glucophage, Glumetza, Glucophage XR, Riomet, Fortamet)
  • Metoprolol Tartrate (metoprolol)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • pantoprazole (Protonix, Protonix IV)
  • prednisone (Deltasone, Rayos, Sterapred DS, Sterapred, Prednicot, Meticorten, Liquid Pred, Orasone, Prednicen-M)
  • simvastatin (Zocor, FloLipid)
  • trazodone (Desyrel, Oleptro, Desyrel Dividose)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin D3 (cholecalciferol)

Tramadol Hydrochloride ER (tramadol) alcohol/food Interactions

There is 1 alcohol/food interaction with Tramadol Hydrochloride ER (tramadol)

Tramadol Hydrochloride ER (tramadol) disease Interactions

There are 9 disease interactions with Tramadol Hydrochloride ER (tramadol) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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