Lyrica Drug Interactions
Currently displaying a list of 286 drugs known to interact with Lyrica (pregabalin).
- 28 major drug interactions
- 257 moderate drug interactions
- 1 minor drug interaction
Medications known to interact with Lyrica
Note: Showing generic names only.
- acetylcarbromal
- acrivastine
- alfentanil
- aliskiren
- allopurinol
- alprazolam
- amitriptyline
- amobarbital
- amoxapine
- apomorphine
- apraclonidine ophthalmic
- aripiprazole
- asenapine
- azatadine
- azelastine nasal
- azilsartan medoxomil
- baclofen
- benazepril
- benztropine
- biperiden
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- buprenorphine
- buspirone
- butabarbital
- butalbital
- butorphanol
- candesartan
- cannabidiol
- cannabis
- captopril
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- cenobamate
- cetirizine
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chloroquine
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorzoxazone
- citalopram
- clemastine
- clobazam
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- codeine
- cyclizine
- cyclobenzaprine
- cyproheptadine
- dantrolene
- daridorexant
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexmedetomidine
- dextromethorphan
- dezocine
- diazepam
- difelikefalin
- dimenhydrinate
- diphenhydramine
- divalproex sodium
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- droperidol
- duloxetine
- enalapril
- enalaprilat
- entacapone
- eprosartan
- escitalopram
- esketamine
- eslicarbazepine
- estazolam
- eszopiclone
- ethanol
- ethchlorvynol
- ethosuximide
- ethotoin
- evening primrose
- ezogabine
- felbamate
- fenfluramine
- fentanyl
- flavoxate
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- fosinopril
- fosphenytoin
- lamotrigine
- lasmiditan
- lemborexant
- levetiracetam
- levocetirizine
- levodopa
- levomethadyl acetate
- levomilnacipran
- levorphanol
- lidocaine
- lisinopril
- lithium
- lofexidine
- lorazepam
- losartan
- loxapine
- lumateperone
- lurasidone
- maprotiline
- meclizine
- mefloquine
- melatonin
- meperidine
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methdilazine
- methocarbamol
- methohexital
- methotrimeprazine
- methsuximide
- metoclopramide
- metyrosine
- midazolam
- milnacipran
- mirabegron
- mirtazapine
- mitotane
- moexipril
- molindone
- morphine
- morphine liposomal
- olanzapine
- oliceridine
- olmesartan
- olopatadine nasal
- opicapone
- opium
- orphenadrine
- oxazepam
- oxcarbazepine
- oxycodone
- oxymorphone
- paliperidone
- paraldehyde
- paramethadione
- paroxetine
- pemoline
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phensuximide
- phenytoin
- pimozide
- pioglitazone
- pramipexole
- primidone
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propiomazine
- propoxyphene
- protriptyline
- pyrilamine
- ramelteon
- ramipril
- rasagiline
- remifentanil
- remimazolam
- risperidone
- ropinirole
- rosiglitazone
- rotigotine
- rufinamide
- safinamide
- scopolamine
- secobarbital
- selegiline
- sertraline
- sibutramine
- sodium oxybate
- st. john's wort
- stiripentol
- sufentanil
- suvorexant
- tapentadol
- tasimelteon
- telmisartan
- temazepam
- tetrabenazine
- thalidomide
- thiethylperazine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- tizanidine
- tolcapone
- topiramate
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- triazolam
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- troglitazone
- valbenazine
- valerian
- valproic acid
- valsartan
- venlafaxine
- vibegron
- vigabatrin
- vilazodone
- vortioxetine
Lyrica alcohol/food interactions
There is 1 alcohol/food interaction with Lyrica (pregabalin).
Lyrica disease interactions
There are 6 disease interactions with Lyrica (pregabalin) which include:
- drug dependence
- suicidal tendency
- angioedema
- creatine kinase elevations
- peripheral edema
- PR interval prolongation
Report options
More about Lyrica (pregabalin)
- Lyrica consumer information
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- Reviews (928)
- Drug images
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Generic availability
- Support group
- FDA approval history
- Drug class: gamma-aminobutyric acid analogs
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
