Metformin/pioglitazone Drug Interactions
Currently displaying a list of 464 drugs known to interact with metformin / pioglitazone.
- 32 major drug interactions
- 420 moderate drug interactions
- 12 minor drug interactions
Medications known to interact with metformin/pioglitazone
Note: Showing generic names only.
A
- abametapir topical
- abemaciclib
- abiraterone
- acalabrutinib
- acarbose
- acetazolamide
- acetohexamide
- adagrasib
- adefovir
- albuterol
- alclometasone topical
- aloe vera
- alpelisib
- alpha-lipoic acid
- amcinonide topical
- amiloride
- aminoglutethimide
- amprenavir
- anisindione
- aprepitant
- aprocitentan
- arimoclomol
- aripiprazole
- armodafinil
- asenapine
- ashwaganda
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atazanavir
B
- bedaquiline
- benazepril
- bendroflumethiazide
- benzphetamine
- benzthiazide
- betamethasone
- betamethasone topical
- bexarotene
- black cohosh
- bortezomib
- bosentan
- brentuximab
- brexpiprazole
- brigatinib
- bromfenac
- bumetanide
- bupropion
C
- calaspargase pegol
- cannabidiol
- capmatinib
- captopril
- carbamazepine
- cariprazine
- celecoxib
- cephalexin
- ceritinib
- chlorothiazide
- chlorotrianisene
- chlorpromazine
- chlorpropamide
- chlorthalidone
- chromic chloride hexahydrate
- chromium picolinate
- cimetidine
- cinnamon
- cinoxacin
- ciprofloxacin
- clarithromycin
- clobetasol topical
- clocortolone topical
- clofarabine
- clopidogrel
- clozapine
- colesevelam
- conjugated estrogens
- conjugated estrogens topical
- copanlisib
- corticorelin
- corticotropin
- cortisone
- cosyntropin
- crizotinib
D
- dabrafenib
- daclatasvir
- daclizumab
- dalfampridine
- danazol
- darunavir
- deferasirox
- deflazacort
- delafloxacin
- delavirdine
- desonide topical
- desoximetasone topical
- dexamethasone
- dexamethasone ophthalmic
- dexamethasone topical
- dexfenfluramine
- diatrizoate
- diazoxide
- dichlorphenamide
- diclofenac
- dicumarol
- dienestrol topical
- diethylpropion
- diethylstilbestrol
- diflorasone topical
- diflunisal
- digoxin
- diltiazem
- dobutamine
- dofetilide
- dolutegravir
- dopamine
- drospirenone
- duvelisib
E
- efavirenz
- enalapril
- enalaprilat
- encorafenib
- enfortumab vedotin
- enoxacin
- entecavir
- ephedrine
- epinephrine
- epirubicin
- erdafitinib
- erythromycin
- esterified estrogens
- estradiol
- estradiol topical
- estramustine
- estrone
- estropipate
- estropipate topical
- ethacrynic acid
- ethanol
- ethinyl estradiol
- etodolac
- etonogestrel
- etranacogene dezaparvovec
- etravirine
- everolimus
F
- fedratinib
- fenfluramine
- fenoprofen
- fexinidazole
- fidanacogene elaparvovec
- fludrocortisone
- fluocinolone topical
- fluocinonide topical
- fluphenazine
- flurandrenolide topical
- flurbiprofen
- fluticasone topical
- fluvoxamine
- formoterol
- fosamprenavir
- fosaprepitant
- fosinopril
- fosphenytoin
- fostamatinib
- furosemide
G
- garlic
- gatifloxacin
- gemfibrozil
- gemifloxacin
- gilteritinib
- ginseng
- givinostat
- glimepiride
- glipizide
- glofitamab
- glucagon
- glyburide
- goserelin
- grepafloxacin
- guanfacine
- guar gum
H
- halcinonide topical
- halobetasol topical
- haloperidol
- heroin
- histrelin
- hydrochlorothiazide
- hydrocortisone
- hydrocortisone topical
- hydroflumethiazide
- hydroxyprogesterone
I
- ibuprofen
- idelalisib
- iloperidone
- imatinib
- inavolisib
- indacaterol
- indapamide
- indinavir
- indomethacin
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- interferon beta-1a
- interferon beta-1b
- iodamide
- iodipamide
- iodixanol
- iohexol
- iomeprol
- iopamidol
- iopromide
- iothalamate
- ioversol
- ioxaglate
- ioxilan
- iptacopan
- isavuconazonium
- isoniazid
- isoproterenol
- itraconazole
- ivosidenib
K
L
- lamotrigine
- lanreotide
- lapatinib
- larotrectinib
- leflunomide
- lenacapavir
- letermovir
- leuprolide
- levofloxacin
- levoketoconazole
- levonorgestrel
- levothyroxine
- levothyroxine / liothyronine
- liothyronine
- liotrix
- lisinopril
- lithium
- lomefloxacin
- lomitapide
- lonapegsomatropin
- loncastuximab tesirine
- lorcaserin
- lumateperone
- lurasidone
M
- ma huang
- mavorixafor
- mazindol
- meclofenamate
- medroxyprogesterone
- mefenamic acid
- megestrol
- meloxicam
- memantine
- mephentermine
- mesoridazine
- metaproterenol
- metaraminol
- methadone
- methamphetamine
- methazolamide
- methdilazine
- methotrexate
- methotrimeprazine
- methoxamine
- methyclothiazide
- methylprednisolone
- methylprednisolone topical
- metolazone
- metrizamide
- mibefradil
- midodrine
- midostaurin
- mifepristone
- mipomersen
- mitapivat
- modafinil
- moexipril
- mometasone topical
- morphine
- moxifloxacin
N
- nabumetone
- nalidixic acid
- naltrexone
- naproxen
- nateglinide
- nefazodone
- nelfinavir
- niacin
- niacinamide
- nicotinamide
- nicotine
- nifedipine
- nilotinib
- niraparib
- nitisinone
- norepinephrine
- norethindrone
- norfloxacin
- norgestrel
O
- octreotide
- ofloxacin
- olanzapine
- olaparib
- olodaterol
- olutasidenib
- omacetaxine
- omaveloxolone
- orlistat
- ospemifene
- oxaprozin
- oxcarbazepine
P
- pacritinib
- paliperidone
- pasireotide
- patiromer
- pazopanib
- pegaspargase
- peginterferon beta-1a
- pegvisomant
- pemetrexed
- pentamidine
- perindopril
- perphenazine
- pexidartinib
- phendimetrazine
- phenobarbital
- phentermine
- phenylbutazone
- phenylephrine
- phenylpropanolamine
- phenytoin
- piroxicam
- pirtobrutinib
- pitolisant
- polythiazide
- porfimer
- pralsetinib
- prednicarbate topical
- prednisolone
- prednisone
- pregabalin
- primidone
- procainamide
- prochlorperazine
- progesterone
- progesterone topical
- promazine
- promethazine
- propiomazine
- pseudoephedrine
Q
R
- raltegravir
- ramipril
- ranitidine
- ranitidine bismuth citrate
- ranolazine
- remdesivir
- repaglinide
- resmetirom
- ribociclib
- rifabutin
- rifampin
- rifapentine
- riociguat
- ripretinib
- risdiplam
- risperidone
- ritodrine
- ritonavir
- rofecoxib
- rucaparib
- rufinamide
S
- salmeterol
- saquinavir
- selpercatinib
- sermorelin
- sibutramine
- simeprevir
- sirolimus
- sirolimus protein-bound
- sofosbuvir
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sparfloxacin
- spironolactone
- stiripentol
- sucralfate
- sulindac
T
- tacrolimus
- tafenoquine
- tagraxofusp
- tazemetostat
- tecovirimat
- temsirolimus
- tenofovir alafenamide
- tenofovir disoproxil
- teprotumumab
- terbutaline
- teriflunomide
- tesamorelin
- thiethylperazine
- thioguanine
- thioridazine
- thyroid desiccated
- thyrotropin alpha
- tipranavir
- tolazamide
- tolbutamide
- tolmetin
- topiramate
- toremifene
- torsemide
- trabectedin
- trandolapril
- triamcinolone
- triamcinolone ophthalmic
- triamcinolone topical
- triamterene
- trichlormethiazide
- trifluoperazine
- triflupromazine
- trilaciclib
- trimeprazine
- trimethoprim
- triptorelin
- trofinetide
- troglitazone
- trospium
- trovafloxacin
- turmeric
V
- vadadustat
- valdecoxib
- valoctocogene roxaparvovec
- vamorolone
- vancomycin
- vandetanib
- varenicline
- vemurafenib
- verapamil
- vilazodone
- vimseltinib
- voriconazole
- vorinostat
W
Z
Metformin/pioglitazone alcohol/food interactions
There are 4 alcohol/food interactions with metformin / pioglitazone.
Metformin/pioglitazone disease interactions
There are 14 disease interactions with metformin / pioglitazone which include:
- lactic acidosis
- liver disease
- renal dysfunction
- CHF
- type I diabetes
- hypoglycemia
- B12 deficiency
- bladder cancer
- edema
- liver disease
- macular edema
- premenopausal anovulation
- weight gain
- anemia
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- During pregnancy
- Drug class: antidiabetic combinations
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
