Orkambi Drug Interactions
Currently displaying a list of 576 drugs known to interact with Orkambi (ivacaftor / lumacaftor).
- 256 major drug interactions
- 306 moderate drug interactions
- 14 minor drug interactions
Medications known to interact with Orkambi
Note: Showing generic names only.
A
- abametapir topical
- abemaciclib
- abiraterone
- abrocitinib
- acalabrutinib
- acetohexamide
- acoramidis
- adagrasib
- afatinib
- albendazole
- alfentanil
- alfuzosin
- aliskiren
- alpelisib
- alprazolam
- ambrisentan
- aminoglutethimide
- amiodarone
- amlodipine
- amobarbital
- amprenavir
- apalutamide
- apixaban
- apremilast
- aprepitant
- aripiprazole
- armodafinil
- artesunate
- asciminib
- ashwaganda
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- astemizole
- atazanavir
- atogepant
- atorvastatin
- atrasentan
- avacopan
- avanafil
- avapritinib
- avatrombopag
- axitinib
B
- bedaquiline
- belumosudil
- belzutifan
- bepridil
- berotralstat
- betamethasone
- betiatide
- betrixaban
- bexarotene
- bicalutamide
- binimetinib
- black cohosh
- boceprevir
- bortezomib
- bosentan
- bosutinib
- brentuximab
- brexpiprazole
- brigatinib
- bromocriptine
- budesonide
- budesonide nasal
- buprenorphine
- bupropion
- buspirone
- busulfan
- butabarbital
- butalbital
- butorphanol
C
- cabazitaxel
- cabozantinib
- calaspargase pegol
- calcifediol
- calcitriol
- cannabidiol
- capivasertib
- capmatinib
- carbamazepine
- cariprazine
- carisoprodol
- carvedilol
- caspofungin
- celecoxib
- cenobamate
- ceritinib
- cerivastatin
- cevimeline
- chloramphenicol
- chloroquine
- chlorotrianisene
- chlorpropamide
- cholecalciferol
- cilostazol
- cimetidine
- ciprofloxacin
- cisapride
- citalopram
- clarithromycin
- clindamycin
- clobazam
- clofarabine
- clofazimine
- clomipramine
- clonazepam
- clopidogrel
- clorazepate
- clotrimazole
- cobicistat
- cobimetinib
- cocaine topical
- codeine
- colchicine
- conivaptan
- conjugated estrogens
- conjugated estrogens topical
- copanlisib
- cortisone
- crinecerfont
- crizotinib
- cyclosporine
D
- dabigatran
- dabrafenib
- daclatasvir
- daclizumab
- danazol
- daprodustat
- dapsone
- dapsone topical
- daridorexant
- darifenacin
- darolutamide
- darunavir
- dasatinib
- daunorubicin
- daunorubicin liposomal
- deferasirox
- deflazacort
- dehydroepiandrosterone
- delavirdine
- dexamethasone
- dexlansoprazole
- diazepam
- diclofenac
- dienestrol topical
- digoxin
- dihydroergotamine
- dihydrotachysterol
- diltiazem
- disopyramide
- docetaxel
- dofetilide
- dolutegravir
- donepezil
- doravirine
- doxercalciferol
- doxorubicin
- doxorubicin liposomal
- dronedarone
- droperidol
- drospirenone
- dutasteride
- duvelisib
E
- echinacea
- edaravone
- edoxaban
- efavirenz
- elacestrant
- elafibranor
- elagolix
- eletriptan
- eliglustat
- eluxadoline
- elvitegravir
- enasidenib
- encorafenib
- enfortumab vedotin
- ensartinib
- ensifentrine
- entrectinib
- enzalutamide
- epirubicin
- eplerenone
- eravacycline
- erdafitinib
- ergocalciferol
- ergonovine
- ergotamine
- erlotinib
- erythromycin
- escitalopram
- eslicarbazepine
- esomeprazole
- estazolam
- esterified estrogens
- estradiol
- estradiol topical
- estrone
- estropipate
- estropipate topical
- eszopiclone
- ethinyl estradiol
- ethosuximide
- etonogestrel
- etoposide
- etranacogene dezaparvovec
- etravirine
- everolimus
- exemestane
F
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fentanyl
- fesoterodine
- fexinidazole
- fexofenadine
- fidanacogene elaparvovec
- fidaxomicin
- finerenone
- flibanserin
- fluconazole
- fludrocortisone
- flurbiprofen
- fluvastatin
- fluvoxamine
- fosamprenavir
- fosaprepitant
- fosphenytoin
- fostamatinib
- fostemsavir
- fruquintinib
- futibatinib
G
- ganaxolone
- gefitinib
- gepirone
- gilteritinib
- givinostat
- glasdegib
- glimepiride
- glipizide
- glyburide
- glycerol phenylbutyrate
- goldenseal
- granisetron
- grepafloxacin
- griseofulvin
- guanfacine
H
- halofantrine
- haloperidol
- halothane
- hydrocodone
- hydrocortisone
- hydroxychloroquine
- hydroxyprogesterone
I
- ibrexafungerp
- ibrutinib
- ibuprofen
- idarubicin
- idelalisib
- iloperidone
- imatinib
- imipramine
- indacaterol
- indinavir
- indomethacin
- infigratinib
- interferon beta-1a
- interferon beta-1b
- iptacopan
- irbesartan
- irinotecan
- irinotecan liposomal
- isavuconazonium
- isoniazid
- isotretinoin
- isradipine
- istradefylline
- itraconazole
- ivabradine
- ivermectin
- ivosidenib
- ixabepilone
- ixazomib
K
L
- lansoprazole
- lapatinib
- larotrectinib
- lazertinib
- lefamulin
- leflunomide
- lemborexant
- lenacapavir
- leniolisib
- lesinurad
- letermovir
- letrozole
- levamlodipine
- levobupivacaine
- levoketoconazole
- levomethadyl acetate
- levonorgestrel
- lidocaine
- linagliptin
- lomitapide
- lonafarnib
- lonapegsomatropin
- loperamide
- loratadine
- lorlatinib
- losartan
- lovastatin
- lumateperone
- lurasidone
- lurbinectedin
- lusutrombopag
M
- macimorelin
- macitentan
- maraviroc
- maribavir
- mavacamten
- mavorixafor
- medroxyprogesterone
- mefenamic acid
- mefloquine
- megestrol
- meloxicam
- mephobarbital
- methadone
- methotrexate
- methylergonovine
- methylprednisolone
- methysergide maleate
- metreleptin
- mibefradil
- miconazole
- midazolam
- midostaurin
- mifepristone
- mipomersen
- mirabegron
- mirtazapine
- mitapivat
- mitotane
- mitoxantrone
- mobocertinib
- modafinil
- momelotinib
- montelukast
- morphine
N
- nafcillin
- naldemedine
- naloxegol
- naltrexone
- naproxen
- nateglinide
- nefazodone
- nelfinavir
- neratinib
- nevirapine
- nicardipine
- nifedipine
- nilotinib
- nilutamide
- nimodipine
- nintedanib
- niraparib
- nirogacestat
- nisoldipine
- nitisinone
- norethindrone
- norgestrel
O
- olaparib
- oliceridine
- olutasidenib
- omaveloxolone
- omeprazole
- oritavancin
- osilodrostat
- osimertinib
- ospemifene
- oxcarbazepine
- oxycodone
- ozanimod
P
- paclitaxel
- paclitaxel protein-bound
- pacritinib
- palbociclib
- palovarotene
- panobinostat
- pantoprazole
- paricalcitol
- pazopanib
- pegaspargase
- peginterferon beta-1a
- pemigatinib
- pentobarbital
- perampanel
- pexidartinib
- phenobarbital
- phenylbutazone
- phenytoin
- pimavanserin
- pimecrolimus topical
- pimozide
- pioglitazone
- pirfenidone
- piroxicam
- pirtobrutinib
- pitolisant
- polatuzumab vedotin
- pomalidomide
- ponatinib
- posaconazole
- pralsetinib
- praziquantel
- prednisolone
- prednisone
- pretomanid
- primidone
- progesterone
- progesterone topical
- propofol
- prucalopride
Q
R
- rabeprazole
- ramelteon
- ranitidine
- ranolazine
- red yeast rice
- regorafenib
- relugolix
- remdesivir
- repaglinide
- repotrectinib
- revumenib
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilpivirine
- rimegepant
- riociguat
- ripretinib
- risperidone
- ritlecitinib
- ritonavir
- rivaroxaban
- roflumilast
- roflumilast topical
- rolapitant
- romidepsin
- rosiglitazone
- rucaparib
- rufinamide
- ruxolitinib
- ruxolitinib topical
S
- safinamide
- saquinavir
- saxagliptin
- secobarbital
- seladelpar
- selegiline
- selinexor
- selpercatinib
- selumetinib
- sertraline
- sildenafil
- silodosin
- simeprevir
- simvastatin
- siponimod
- sirolimus
- sirolimus protein-bound
- solifenacin
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sonidegib
- sorafenib
- sotorasib
- sparsentan
- st. john's wort
- stiripentol
- sufentanil
- sulfamethoxazole
- sulfinpyrazone
- sunitinib
- suvorexant
- suzetrigine
T
- tacrolimus
- tadalafil
- talazoparib
- tamoxifen
- tasimelteon
- tazemetostat
- tecovirimat
- tedizolid
- telaprevir
- telisotuzumab vedotin
- telithromycin
- telotristat
- temsirolimus
- tepotinib
- terfenadine
- teriflunomide
- thioguanine
- thiotepa
- ticagrelor
- tipranavir
- tisotumab vedotin
- tivozanib
- tofacitinib
- tolazamide
- tolbutamide
- tolterodine
- tolvaptan
- toremifene
- torsemide
- tovorafenib
- trabectedin
- tramadol
- treosulfan
- treprostinil
- tretinoin
- triamcinolone
- triazolam
- trimethoprim
- trofinetide
- troglitazone
- troleandomycin
- tucatinib
U
V
- vadadustat
- valbenazine
- valdecoxib
- valoctocogene roxaparvovec
- vamorolone
- vandetanib
- vardenafil
- vemurafenib
- venetoclax
- venlafaxine
- verapamil
- vibegron
- vilazodone
- viloxazine
- vinblastine
- vincristine
- vincristine liposome
- vinorelbine
- voclosporin
- vonoprazan
- vorapaxar
- vorasidenib
- voriconazole
- vortioxetine
- voxelotor
W
Z
Orkambi alcohol/food interactions
There are 2 alcohol/food interactions with Orkambi (ivacaftor / lumacaftor).
Orkambi disease interactions
There are 6 disease interactions with Orkambi (ivacaftor / lumacaftor) which include:
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More about Orkambi (ivacaftor / lumacaftor)
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- FDA approval history
- Drug class: CFTR combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
