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CFTR combinations

What are CFTR combinations?

The Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene codes the function of the chloride ion channel which is at the surface of some epithelial cells. Mutations to the CFTR gene causes defects in chloride transport that leads to an alteration of epithelial fluid transport in the lung and other organs, which causes cystic fibrosis. CFTR potentiators repair defects in chloride transport, and are used to treat cystic fibrosis patients with a specific gene mutation. CFTR combinations drugs are when more than one CFTR potentiator is combined into one drug for increased efficacy.

List of CFTR combinations

View by  Brand | Generic
Drug Name Avg. Rating Reviews
Trikafta (Pro)
Generic name: elexacaftor / ivacaftor / tezacaftor
1 review
Symdeko (Pro)
Generic name: ivacaftor / tezacaftor
No reviews
Orkambi (Pro)
Generic name: ivacaftor / lumacaftor
No reviews
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

See also

Medical conditions associated with CFTR combinations:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.