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Drug Interactions between momelotinib and Orkambi

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

lumacaftor momelotinib

Applies to: Orkambi (ivacaftor / lumacaftor) and momelotinib

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with potent CYP450 3A4 inducers may decrease the plasma concentration and therapeutic effects of momelotinib. The proposed mechanism is increased metabolism of momelotinib via the CYP450 3A4 isoenzyme. However, momelotinib is metabolized by multiple pathways and so the clinical significance is unclear. In a phase I study, coadministration of multiple doses of rifampin (600 mg once daily) following a single dose of momelotinib (200 mg) reduced the Cmax and AUC of momelotinib by 29% and 46%, respectively, when compared with a single dose of momelotinib (200 mg) plus a single dose of rifampin (600 mg). No data are available for use with other, less potent inducers.

MANAGEMENT: Caution and monitoring for decreased momelotinib efficacy may be required when used concomitantly with potent CYP450 3A4 inducers. An alternative agent with less potential for induction should be considered if possible.

Drug and food interactions

Moderate

ivacaftor food

Applies to: Orkambi (ivacaftor / lumacaftor)

Ivacaftor should be taken with fat-containing foods such as eggs, avocados, nuts, meat, butter, peanut butter, cheese pizza, and whole-milk dairy products to help with its absorption. Do not consume grapefruit juice or any food that contains grapefruit or Seville oranges during treatment with ivacaftor unless directed otherwise by your doctor. Grapefruit juice can significantly increase the blood levels of ivacaftor. This may increase the risk and/or severity of serious side effects such as liver damage. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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