Vagifem Drug Interactions
Currently displaying a list of 258 drugs known to interact with Vagifem (estradiol topical).
- 33 major drug interactions
- 209 moderate drug interactions
- 16 minor drug interactions
Medications known to interact with Vagifem
Note: Showing generic names only.
A
- abametapir topical
- abrocitinib
- acarbose
- acetohexamide
- adagrasib
- albiglutide
- alogliptin
- alosetron
- aminoglutethimide
- amitriptyline
- amobarbital
- amoxapine
- anagrelide
- anastrozole
- anisindione
- apalutamide
- aprepitant
- asciminib
- asenapine
- atorvastatin
- avacopan
B
- baricitinib
- belzutifan
- bendamustine
- berotralstat
- betamethasone
- bexagliflozin
- bexarotene
- boceprevir
- bosentan
- budesonide
- butabarbital
- butalbital
C
- C1 esterase inhibitor (human)
- calcipotriene topical
- calcitriol topical
- canagliflozin
- carbamazepine
- carfilzomib
- cenobamate
- chenodiol
- chloramphenicol
- chlorpropamide
- cimetidine
- clarithromycin
- clomipramine
- clotrimazole
- conestat alfa
- conivaptan
- corticorelin
- corticotropin
- cortisone
- cosyntropin
D
- dabrafenib
- dantrolene
- dapagliflozin
- daridorexant
- darunavir
- dasatinib
- deflazacort
- dehydroepiandrosterone
- desipramine
- dexamethasone
- dicumarol
- diltiazem
- divalproex sodium
- doxepin
- dronedarone
- dulaglutide
- duloxetine
- duvelisib
E
- echinacea
- efavirenz
- elafibranor
- elagolix
- empagliflozin
- encorafenib
- enzalutamide
- ertugliflozin
- erythromycin
- eslicarbazepine
- etravirine
- exemestane
- exenatide
F
- fedratinib
- felbamate
- fenfluramine
- fexinidazole
- fezolinetant
- fluconazole
- fludrocortisone
- fluvoxamine
- fosaprepitant
- fosphenytoin
- fostamatinib
G
H
I
- imatinib
- imipramine
- indinavir
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- iptacopan
- isavuconazonium
- itraconazole
- ivacaftor
- ivosidenib
K
L
- lamotrigine
- larotrectinib
- lefamulin
- lenacapavir
- lenalidomide
- letermovir
- letrozole
- levobupivacaine
- levoketoconazole
- levothyroxine
- levothyroxine / liothyronine
- lidocaine
- linagliptin
- liothyronine
- liotrix
- liraglutide
- lixisenatide
- lonafarnib
- lonapegsomatropin
- lorlatinib
M
- mavacamten
- mephobarbital
- metformin
- methylprednisolone
- metreleptin
- metyrapone
- mibefradil
- miconazole
- mifepristone
- miglitol
- mitapivat
- mitotane
- mobocertinib
- momelotinib
N
O
P
- pacritinib
- pentobarbital
- phenobarbital
- phenylbutazone
- phenytoin
- pioglitazone
- pirfenidone
- pirtobrutinib
- pitolisant
- pomalidomide
- posaconazole
- pralsetinib
- pramlintide
- prednisolone
- prednisone
- primidone
- protriptyline
R
- raloxifene
- ramelteon
- rasagiline
- repaglinide
- repotrectinib
- rifabutin
- rifampin
- rifapentine
- ritlecitinib
- roflumilast
- ropinirole
- rosiglitazone
- rucaparib
- ruxolitinib
- ruxolitinib topical
S
- saquinavir
- saw palmetto
- saxagliptin
- secobarbital
- selpercatinib
- semaglutide
- sirolimus
- sitagliptin
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sotagliflozin
- sotorasib
- st. john's wort
- succinylcholine
- sulfinpyrazone
- suzetrigine
T
- tacrolimus
- tasimelteon
- tazemetostat
- tecovirimat
- telaprevir
- telithromycin
- telotristat
- temsirolimus
- testolactone
- thalidomide
- thyroid desiccated
- tipranavir
- tirzepatide
- tizanidine
- tofacitinib
- tolazamide
- tolbutamide
- tovorafenib
- tranexamic acid
- triamcinolone
- triamcinolone ophthalmic
- trimipramine
- trofinetide
- troglitazone
- troleandomycin
- tucatinib
U
V
W
Z
Vagifem alcohol/food interactions
There are 2 alcohol/food interactions with Vagifem (estradiol topical).
Vagifem disease interactions
There are 17 disease interactions with Vagifem (estradiol topical) which include:
- abnormal vaginal bleeding
- carcinomas (estrogenic)
- hypercalcemia in breast cancer
- hypertension
- thromboembolism/cardiovascular
- hepatic neoplasms
- angioedema
- gallbladder disease
- hypercalcemia
- hyperlipidemia
- liver disease
- melasma
- depression
- fluid retention
- glucose intolerance
- retinal thrombosis
- thyroid function tests
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.