Sinemet Drug Interactions
Currently displaying a list of 520 drugs known to interact with Sinemet (carbidopa / levodopa).
- 50 major drug interactions
- 459 moderate drug interactions
- 11 minor drug interactions
Medications known to interact with Sinemet
Note: Showing generic names only.
5
A
- acebutolol
- acetazolamide
- acetylcarbromal
- acrivastine
- adalimumab
- ado-trastuzumab emtansine
- alfentanil
- alfuzosin
- allopurinol
- alprazolam
- alprostadil
- aluminum carbonate
- aluminum hydroxide
- amantadine
- ambrisentan
- amifostine
- amiloride
- amiodarone
- amisulpride
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amphetamine
- amyl nitrite
- apomorphine
- apraclonidine ophthalmic
- aprocitentan
- aripiprazole
- asenapine
- atenolol
- atorvastatin
- atropine
- auranofin
- aurothioglucose
- axicabtagene ciloleucel
- azatadine
- azelastine nasal
- azilsartan medoxomil
B
- baclofen
- belladonna
- benazepril
- bendroflumethiazide
- benznidazole
- benzthiazide
- benztropine
- bepridil
- betaxolol
- biperiden
- bisoprolol
- bortezomib
- brentuximab
- brexanolone
- brexpiprazole
- brexucabtagene autoleucel
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- bumetanide
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- cabazitaxel
- calcium carbonate
- candesartan
- cannabidiol
- cannabis
- captopril
- carbamazepine
- carbetapentane
- carbinoxamine
- carbonyl iron
- carboplatin
- carfilzomib
- cariprazine
- carisoprodol
- carteolol
- carvedilol
- cenobamate
- cerivastatin
- certolizumab
- chlophedianol
- chloral hydrate
- chloramphenicol
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chloroquine
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorthalidone
- chlorzoxazone
- ciltacabtagene autoleucel
- cisplatin
- citalopram
- citicoline
- clemastine
- clevidipine
- clidinium
- clobazam
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- codeine
- colchicine
- crizotinib
- cyclandelate
- cyclizine
- cyclobenzaprine
- cyproheptadine
D
- dantrolene
- dapsone
- daridorexant
- darifenacin
- deserpidine
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexmedetomidine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dichlorphenamide
- dicyclomine
- didanosine
- difelikefalin
- dihydroxyaluminum sodium carbonate
- diltiazem
- dimenhydrinate
- dinutuximab
- diphenhydramine
- disulfiram
- divalproex sodium
- dobutamine
- docetaxel
- doxazosin
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- droperidol
- droxidopa
- duloxetine
E
- efavirenz
- elotuzumab
- elranatamab
- enalapril
- enalaprilat
- enfortumab vedotin
- entacapone
- ephedrine
- epinephrine
- eplerenone
- eprosartan
- eribulin
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- estazolam
- eszopiclone
- etanercept
- ethacrynic acid
- ethambutol
- ethanol
- ethaverine
- ethchlorvynol
- ethionamide
- ethosuximide
- ethotoin
- etoposide
- etravirine
- ezogabine
F
- felbamate
- felodipine
- fenfluramine
- fentanyl
- ferric citrate
- ferric maltol
- ferrous fumarate
- ferrous gluconate
- ferrous sulfate
- flavoxate
- flibanserin
- fludarabine
- fluoxetine
- fluphenazine
- flurazepam
- fluvastatin
- fluvoxamine
- fosinopril
- fosphenytoin
- furazolidone
- furosemide
G
- gabapentin
- gabapentin enacarbil
- ganaxolone
- glofitamab
- glycopyrrolate
- gold sodium thiomalate
- golimumab
- guanabenz
- guanadrel
- guanethidine
- guanfacine
H
- halazepam
- haloperidol
- heme iron polypeptide
- heroin
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydroflumethiazide
- hydromorphone
- hydroxychloroquine
- hydroxyzine
- hyoscyamine
I
- idecabtagene vicleucel
- ifosfamide
- iloperidone
- imipramine
- inamrinone
- indapamide
- infliximab
- interferon alfa-2a
- interferon alfa-2b
- interferon alfa-n1
- interferon alfacon-1
- iodoquinol
- ipilimumab
- irbesartan
- iron bisglycinate
- iron polysaccharide
- iron protein succinylate
- isocarboxazid
- isoniazid
- isoproterenol
- isosorbide dinitrate
- isosorbide mononitrate
- isoxsuprine
- isradipine
- ixabepilone
- ixazomib
K
L
- labetalol
- lamotrigine
- landiolol
- lasmiditan
- leflunomide
- lemborexant
- levamlodipine
- levetiracetam
- levomethadyl acetate
- levorphanol
- lidocaine
- linezolid
- lisinopril
- lisocabtagene maraleucel
- lithium
- lofexidine
- lorazepam
- losartan
- lovastatin
- loxapine
- lumateperone
- lurasidone
M
- macimorelin
- macitentan
- magaldrate
- magnesium carbonate
- magnesium hydroxide
- magnesium oxide
- mannitol
- maprotiline
- mecamylamine
- meclizine
- melatonin
- memantine
- mepenzolate
- meperidine
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methazolamide
- methdilazine
- methocarbamol
- methohexital
- methotrimeprazine
- methscopolamine
- methsuximide
- methyclothiazide
- methyldopa
- methylene blue
- metoclopramide
- metolazone
- metoprolol
- metronidazole
- metyrosine
- mibefradil
- midazolam
- milrinone
- minoxidil
- mirtazapine
- mirvetuximab soravtansine
- mitotane
- moexipril
- molindone
- morphine
- morphine liposomal
- mosunetuzumab
- multivitamin with iron
- multivitamin with iron and fluoride
- multivitamin with minerals
- multivitamin, prenatal
N
- nabilone
- nadolol
- nalbuphine
- naxitamab
- nebivolol
- nefazodone
- nelarabine
- nicardipine
- nifedipine
- nimodipine
- nisoldipine
- nitrofurantoin
- nitroglycerin
- nitroprusside
- norepinephrine
- nortriptyline
O
- olanzapine
- oliceridine
- olmesartan
- opicapone
- opium
- orphenadrine
- oxaliplatin
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
- ozanimod
P
- paclitaxel
- paclitaxel protein-bound
- paliperidone
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- peginterferon alfa-2a
- peginterferon alfa-2b
- penbutolol
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phenoxybenzamine
- phensuximide
- phentolamine
- phenylephrine
- phenylpropanolamine
- phenytoin
- pimozide
- pindolol
- pitavastatin
- polatuzumab vedotin
- polythiazide
- pomalidomide
- ponatinib
- pramipexole
- pravastatin
- prazosin
- pregabalin
- primidone
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propantheline
- propiomazine
- propoxyphene
- propranolol
- protriptyline
- pseudoephedrine
- pyridoxine
- pyrilamine
Q
R
- ramelteon
- ramipril
- rasagiline
- rauwolfia serpentina
- red yeast rice
- remifentanil
- remimazolam
- repotrectinib
- reserpine
- risperidone
- ropinirole
- rosuvastatin
- rotigotine
- rufinamide
S
- safinamide
- sapropterin
- scopolamine
- secnidazole
- secobarbital
- selegiline
- selinexor
- sertraline
- sibutramine
- silodosin
- simvastatin
- sodium bicarbonate
- sodium oxybate
- solifenacin
- solriamfetol
- sotalol
- sparsentan
- spironolactone
- st. john's wort
- stavudine
- stiripentol
- sufentanil
- suvorexant
T
- talquetamab
- tamsulosin
- tapentadol
- tarlatamab
- tasimelteon
- teclistamab
- telbivudine
- telmisartan
- temazepam
- teniposide
- terazosin
- teriflunomide
- tetrabenazine
- thalidomide
- thiethylperazine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- timolol
- tinidazole
- tisagenlecleucel
- tisotumab vedotin
- tizanidine
- tocilizumab
- tolazoline
- tolcapone
- tolterodine
- topiramate
- torsemide
- trabectedin
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- triamterene
- triazolam
- trichlormethiazide
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- trospium
V
- valbenazine
- valerian
- valproic acid
- valsartan
- venlafaxine
- verapamil
- vigabatrin
- vinblastine
- vincristine
- vincristine liposome
- vinorelbine
Z
Sinemet alcohol/food interactions
There is 1 alcohol/food interaction with Sinemet (carbidopa / levodopa).
Sinemet disease interactions
There are 13 disease interactions with Sinemet (carbidopa / levodopa) which include:
- glaucoma
- cardiac disease
- neuroleptic malignant syndrome
- psychoses/depression
- glaucoma
- liver/renal
- melanoma
- reactive airway disease
- depression
- sleep disorders
- hypotension
- psychosis
- GI bleeding
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- Drug class: dopaminergic antiparkinsonism agents
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
