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Drug interactions between rasagiline and Sinemet

Results for the following 2 drugs:
Sinemet (carbidopa/levodopa)

Interactions between your drugs


levodopa ↔ rasagiline

Applies to:Sinemet (carbidopa/levodopa) and rasagiline

The side effects of levodopa may be increased when it is used in combination with rasagiline. You may need a dose adjustment if you have been taking levodopa and are starting treatment with rasagiline. Contact your doctor if you experience hallucinations, confusion, loss of muscle control, or movement difficulties during treatment with these medications. You may also experience low blood pressure, especially during the first two months of treatment with rasagiline or after a dose increase at anytime during treatment. Symptoms may include dizziness, lightheadedness, flushing, fainting, and/or a rapid heart rate. Although these symptoms tend to go away over time, let your doctor know if they become troublesome or interfere with your daily activities, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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