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Sinemet: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on Nov 6, 2023.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Sinemet is a medication that may be used for the treatment of Parkinson's disease that is available in three different strengths: Sinemet 25/100, Sinemet 25/250, and Sinemet 10/100. Dyskinesias (abnormal involuntary movements) and nausea are the main side effects and it may discolor saliva, urine, and sweat a dark red, brown, or black. It may increase the risk of depression, and melanoma, and affect impulse control. Tablets need to be taken frequently throughout the day and dosage reductions or discontinuations have been uncommonly associated with a symptom complex resembling NMS).

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with Sinemet may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with Sinemet. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with Sinemet include:

Avoid drinking alcohol or taking illegal or recreational drugs while taking Sinemet.

Sinemet may be given to people receiving supplemental pyridoxine (vitamin B6) because carbidopa inhibits the pyridoxine-increased decarboxylation of levodopa.

Note that this list is not all-inclusive and includes only common medications that may interact with Sinemet. You should refer to the prescribing information for Sinemet for a complete list of interactions.


Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Sinemet only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2024 Revision date: November 6, 2023.