HistaFlex Interactions
There are 532 drugs known to interact with HistaFlex (acetaminophen / pyrilamine), along with 10 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 19 are major, 499 are moderate, and 14 are minor.
- View HistaFlex alcohol/food interactions (1)
- View HistaFlex disease interactions (10)
Medications known to interact with HistaFlex
Note: Showing generic names only.
A
- abobotulinumtoxinA
- acebutolol
- acetylcarbromal
- acetylcholine ophthalmic
- aclidinium
- acrivastine
- aldesleukin
- alfentanil
- alfuzosin
- allopurinol
- alprazolam
- amantadine
- amiloride
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amyl nitrite
- anagrelide
- anisindione
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- aprocitentan
- aripiprazole
- asenapine
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atenolol
- atezolizumab
- atropine
- avelumab
- azatadine
- azelastine nasal
- azilsartan medoxomil
B
- baclofen
- bedaquiline
- belladonna
- benazepril
- bendroflumethiazide
- benoxinate ophthalmic
- benzgalantamine
- benzocaine topical
- benzthiazide
- benztropine
- bepridil
- betaxolol
- biperiden
- bisoprolol
- black cohosh
- brentuximab
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- bumetanide
- bupivacaine
- bupivacaine liposome
- buprenorphine
- bupropion
- buspirone
- busulfan
- butabarbital
- butalbital
- butorphanol
C
- calaspargase pegol
- candesartan
- cannabidiol
- cannabis
- captopril
- carbachol ophthalmic
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carteolol
- carvedilol
- cemiplimab
- cenobamate
- ceritinib
- cetirizine
- charcoal
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chloroprocaine
- chloroprocaine ophthalmic
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorthalidone
- chlorzoxazone
- cholestyramine
- cimetidine
- citalopram
- clemastine
- clevidipine
- clidinium
- clobazam
- clofarabine
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- cocaine nasal
- cocaine topical
- codeine
- cosibelimab
- cyclizine
- cyclobenzaprine
- cyproheptadine
D
- daclizumab
- dantrolene
- daridorexant
- darifenacin
- daxibotulinumtoxinA
- deferasirox
- demecarium bromide ophthalmic
- deserpidine
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexmedetomidine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dibucaine topical
- dicumarol
- dicyclomine
- difelikefalin
- diflunisal
- diltiazem
- dimenhydrinate
- diphenhydramine
- disopyramide
- divalproex sodium
- donepezil
- dostarlimab
- doxazosin
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- droperidol
- duloxetine
- durvalumab
E
- echinacea
- echothiophate iodide ophthalmic
- efavirenz
- eluxadoline
- enalapril
- enalaprilat
- encorafenib
- entacapone
- epirubicin
- eplerenone
- eprosartan
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- estazolam
- eszopiclone
- ethacrynic acid
- ethanol
- ethchlorvynol
- ethinyl estradiol
- ethosuximide
- ethotoin
- etidocaine
- etranacogene dezaparvovec
- ezogabine
F
- felbamate
- felodipine
- fenfluramine
- fenofibrate
- fenoldopam
- fentanyl
- fesoterodine
- fexinidazole
- fidanacogene elaparvovec
- flavoxate
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- fosinopril
- fosphenytoin
- fospropofol
- furazolidone
- furosemide
G
- gabapentin
- gabapentin enacarbil
- galantamine
- ganaxolone
- givosiran
- glycerol phenylbutyrate
- glycopyrrolate
- glycopyrronium topical
- guanabenz
- guanadrel
- guanethidine
- guanfacine
H
- halazepam
- haloperidol
- heroin
- histamine phosphate
- house dust mite allergen extract
- hyaluronidase
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydroflumethiazide
- hydromorphone
- hydroxyprogesterone
- hydroxyzine
- hyoscyamine
I
- idelalisib
- ifosfamide
- iloperidone
- imatinib
- imipramine
- incobotulinumtoxinA
- indapamide
- interferon beta-1a
- interferon beta-1b
- ipilimumab
- ipratropium
- ipratropium nasal
- irbesartan
- isocarboxazid
- isoflurophate ophthalmic
- isoniazid
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
K
L
- labetalol
- lamotrigine
- landiolol
- lasmiditan
- leflunomide
- lemborexant
- leniolisib
- letibotulinumtoxinA
- levamlodipine
- levetiracetam
- levobupivacaine
- levocetirizine
- levodopa
- levoketoconazole
- levomethadyl acetate
- levorphanol
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- linezolid
- liraglutide
- lisinopril
- lithium
- lofexidine
- lomitapide
- loperamide
- lorazepam
- lorlatinib
- losartan
- loxapine
- lumateperone
- lurasidone
M
- maprotiline
- mavorixafor
- meclizine
- melatonin
- mepenzolate
- meperidine
- mephenytoin
- mephobarbital
- mepivacaine
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methdilazine
- methocarbamol
- methohexital
- methotrexate
- methotrimeprazine
- methscopolamine
- methsuximide
- methyclothiazide
- methyldopa
- metoclopramide
- metolazone
- metoprolol
- metyrosine
- mibefradil
- midazolam
- minoxidil
- mipomersen
- mirtazapine
- mitotane
- mixed grass pollens allergen extract
- moexipril
- molindone
- morphine
- morphine liposomal
N
- nabilone
- nadolol
- nalbuphine
- naltrexone
- nebivolol
- nefazodone
- nicardipine
- nicotine
- nifedipine
- nimodipine
- niraparib
- nisoldipine
- nitroglycerin
- nitroprusside
- nivolumab
- nortriptyline
O
- olanzapine
- oliceridine
- olmesartan
- olopatadine nasal
- olutasidenib
- omaveloxolone
- onabotulinumtoxinA
- opicapone
- opium
- orphenadrine
- ospemifene
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
P
- paliperidone
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- peanut allergen powder
- pegaspargase
- peginterferon beta-1a
- pembrolizumab
- penbutolol
- penpulimab
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- pexidartinib
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phenoxybenzamine
- phensuximide
- phentolamine
- phenytoin
- physostigmine
- physostigmine ophthalmic
- pilocarpine ophthalmic
- pimozide
- pindolol
- pirtobrutinib
- pitolisant
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 7-valent vaccine
- polythiazide
- potassium chloride
- potassium citrate
- prabotulinumtoxinA
- pralsetinib
- pramipexole
- pramoxine topical
- prazosin
- pregabalin
- primidone
- probenecid
- procaine
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propantheline
- proparacaine ophthalmic
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
Q
R
- ragweed pollen allergen extract
- ramelteon
- ramipril
- ranitidine
- ranitidine bismuth citrate
- rasagiline
- rauwolfia serpentina
- remdesivir
- remifentanil
- remimazolam
- reserpine
- retifanlimab
- revefenacin
- rifampin
- rimabotulinumtoxinB
- risperidone
- ritlecitinib
- rivastigmine
- ropinirole
- ropivacaine
- rotigotine
- rucaparib
- rufinamide
S
- safinamide
- scopolamine
- secobarbital
- selegiline
- sertraline
- sibutramine
- silodosin
- sodium iodide i-123
- sodium iodide-i-131
- sodium oxybate
- sodium salicylate
- solifenacin
- sotalol
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- sufentanil
- sulfinpyrazone
- suvorexant
T
- tacrine
- tafamidis
- tamsulosin
- tapentadol
- tasimelteon
- telmisartan
- temazepam
- terazosin
- teriflunomide
- tetrabenazine
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- thalidomide
- thiethylperazine
- thioguanine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- timolol
- timothy grass pollen allergen extract
- tiotropium
- tirzepatide
- tislelizumab
- tizanidine
- tolcapone
- tolterodine
- topiramate
- toripalimab
- torsemide
- trabectedin
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- tremelimumab
- triamterene
- triazolam
- trichlormethiazide
- trichophyton skin test
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- trospium
U
V
- valbenazine
- valerian
- valoctocogene roxaparvovec
- valproic acid
- valsartan
- varenicline
- vemurafenib
- venlafaxine
- verapamil
- vigabatrin
W
Z
HistaFlex alcohol/food interactions
There is 1 alcohol/food interaction with HistaFlex (acetaminophen / pyrilamine).
HistaFlex disease interactions
There are 10 disease interactions with HistaFlex (acetaminophen / pyrilamine) which include:
- alcoholism
- liver disease
- depression
- PKU
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
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More about HistaFlex (acetaminophen / pyrilamine)
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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