Acetaminophen/ibuprofen Drug Interactions
Currently displaying a list of 518 drugs known to interact with acetaminophen / ibuprofen.
- 100 major drug interactions
- 378 moderate drug interactions
- 40 minor drug interactions
Medications known to interact with acetaminophen/ibuprofen
Note: Showing generic names only.
A
- abciximab
- abrocitinib
- acalabrutinib
- acebutolol
- acetohexamide
- adagrasib
- adefovir
- ado-trastuzumab emtansine
- alemtuzumab
- alendronate
- aliskiren
- alpelisib
- alteplase
- ambenonium
- amikacin
- amikacin liposome
- amiloride
- aminolevulinic acid
- aminolevulinic acid topical
- amlodipine
- amobarbital
- anagrelide
- anisindione
- anistreplase
- antithrombin (recombinant)
- antithrombin iii
- apalutamide
- apixaban
- aprepitant
- ardeparin
- argatroban
- asciminib
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- aspirin
- atenolol
- atezolizumab
- atropine
- avapritinib
- avelumab
- azilsartan medoxomil
B
- balsalazide
- baricitinib
- bedaquiline
- belladonna
- benazepril
- bendroflumethiazide
- benoxinate ophthalmic
- benzgalantamine
- benzocaine topical
- benzthiazide
- benztropine
- bepridil
- betamethasone
- betaxolol
- betiatide
- betrixaban
- biperiden
- bisoprolol
- bivalirudin
- black cohosh
- bosentan
- botulism immune globulin
- brentuximab
- bromfenac
- budesonide
- bumetanide
- bupivacaine
- bupivacaine liposome
- bupropion
- busulfan
- butabarbital
- butalbital
C
- cabozantinib
- calaspargase pegol
- candesartan
- cangrelor
- cannabidiol
- caplacizumab
- captopril
- carbamazepine
- carteolol
- carvedilol
- celecoxib
- cemiplimab
- ceritinib
- charcoal
- chloroprocaine
- chloroprocaine ophthalmic
- chlorothiazide
- chlorpropamide
- chlorthalidone
- cholestyramine
- cidofovir
- cilostazol
- cimetidine
- cinoxacin
- ciprofloxacin
- citalopram
- clidinium
- clofarabine
- clomipramine
- clopidogrel
- clove
- cocaine nasal
- cocaine topical
- cortisone
- cosibelimab
- cyclosporine
- cytomegalovirus immune globulin
D
- dabigatran
- dabrafenib
- daclizumab
- dalteparin
- danaparoid
- daprodustat
- daptomycin
- darifenacin
- dasatinib
- deferasirox
- defibrotide
- deflazacort
- delafloxacin
- desirudin
- desmopressin
- desvenlafaxine
- dexamethasone
- dexfenfluramine
- diatrizoate
- dibucaine topical
- diclofenac
- diclofenac topical
- dicumarol
- dicyclomine
- diflunisal
- digoxin
- diltiazem
- dimethyl fumarate
- dipyridamole
- diroximel fumarate
- divalproex sodium
- donepezil
- dostarlimab
- drospirenone
- drotrecogin alfa
- duloxetine
- durvalumab
E
- echinacea
- edoxaban
- edrophonium
- efavirenz
- enalapril
- enalaprilat
- encorafenib
- enoxacin
- enoxaparin
- entecavir
- enzalutamide
- epirubicin
- eplerenone
- epoprostenol
- eprosartan
- eptifibatide
- erlotinib
- escitalopram
- esmolol
- ethacrynic acid
- ethanol
- ethinyl estradiol
- ethotoin
- etidocaine
- etidronate
- etodolac
- etranacogene dezaparvovec
- etravirine
- everolimus
- exenatide
F
- famotidine
- felodipine
- fenfluramine
- fenofibrate
- fenoldopam
- fenoprofen
- fexinidazole
- fidanacogene elaparvovec
- flavoxate
- flucytosine
- fludrocortisone
- fluoxetine
- flurbiprofen
- fluvoxamine
- fondaparinux
- fosaprepitant
- fosinopril
- fosphenytoin
- furosemide
G
- galantamine
- ganciclovir
- gatifloxacin
- gemifloxacin
- gentamicin
- ginkgo
- givosiran
- glimepiride
- glipizide
- glyburide
- glycerol phenylbutyrate
- glycopyrrolate
- grepafloxacin
- guanidine
H
- heparin
- heparin flush
- horse chestnut
- house dust mite allergen extract
- hydralazine
- hydrochlorothiazide
- hydrocortisone
- hydroflumethiazide
- hydroxyprogesterone
- hyoscyamine
I
- ibandronate
- ibritumomab
- ibrutinib
- icosapent
- idelalisib
- iloprost
- imatinib
- immune globulin intravenous
- immune globulin intravenous and subcutaneous
- indapamide
- indomethacin
- inotersen
- interferon beta-1a
- interferon beta-1b
- iodamide
- iodine i 131 tositumomab
- iodipamide
- iodixanol
- iohexol
- iomeprol
- iopamidol
- iopromide
- iothalamate
- ioversol
- ioxaglate
- ioxilan
- ipilimumab
- irbesartan
- isoniazid
- isradipine
- ivacaftor
- ivosidenib
K
L
- labetalol
- landiolol
- leflunomide
- leniolisib
- lepirudin
- letermovir
- levamlodipine
- levobupivacaine
- levofloxacin
- levoketoconazole
- levomilnacipran
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- linaclotide
- liraglutide
- lisinopril
- lithium
- lomefloxacin
- lomitapide
- lorlatinib
- losartan
- lvp solution with potassium
M
- macimorelin
- magnesium hydroxide
- mavacamten
- mavorixafor
- meclofenamate
- mefenamic acid
- meloxicam
- mepenzolate
- mephenytoin
- mephobarbital
- mepivacaine
- mesalamine
- metformin
- methohexital
- methotrexate
- methoxsalen
- methoxyflurane
- methscopolamine
- methyclothiazide
- methyl aminolevulinate topical
- methylprednisolone
- metoclopramide
- metolazone
- metoprolol
- metrizamide
- mifepristone
- milnacipran
- mipomersen
- mitapivat
- mixed grass pollens allergen extract
- moexipril
- monomethyl fumarate
- moxifloxacin
N
- nabumetone
- nadolol
- nalidixic acid
- naltrexone
- naproxen
- nateglinide
- nebivolol
- neostigmine
- netilmicin
- nicardipine
- nicotine
- nifedipine
- nimodipine
- nintedanib
- niraparib
- nisoldipine
- nitisinone
- nivolumab
- nizatidine
- norfloxacin
O
- ofloxacin
- olmesartan
- olsalazine
- olutasidenib
- omacetaxine
- omaveloxolone
- omega-3 polyunsaturated fatty acids
- oritavancin
- ospemifene
- oxaliplatin
- oxaprozin
- oxazepam
- oxybutynin
P
- pamidronate
- panobinostat
- paroxetine
- peanut allergen powder
- pegaspargase
- peginterferon beta-1a
- pembrolizumab
- pemetrexed
- penbutolol
- penpulimab
- pentobarbital
- pentoxifylline
- perindopril
- pexidartinib
- phenobarbital
- phenylbutazone
- phenytoin
- physostigmine
- pindolol
- piroxicam
- pirtobrutinib
- pitolisant
- plasminogen, human
- plazomicin
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 7-valent vaccine
- polyethylene glycol 3350 with electrolytes
- polythiazide
- ponatinib
- porfimer
- potassium acid phosphate
- potassium aminobenzoate
- potassium bicarbonate
- potassium chloride
- potassium citrate
- potassium gluconate
- potassium iodide
- potassium perchlorate
- potassium phosphate
- pralatrexate
- pralsetinib
- pramoxine topical
- prasugrel
- prazosin
- prednisolone
- prednisone
- primidone
- probenecid
- procaine
- procyclidine
- propantheline
- proparacaine ophthalmic
- propranolol
- pyridostigmine
Q
R
- ragweed pollen allergen extract
- ramipril
- ramucirumab
- ranitidine
- ranitidine bismuth citrate
- regorafenib
- remdesivir
- repaglinide
- respiratory syncytial virus immune globulin
- reteplase
- retifanlimab
- revakinagene taroretcel
- rho (d) immune globulin
- rifampin
- rifapentine
- risedronate
- ritlecitinib
- ritonavir
- rivaroxaban
- rivastigmine
- rofecoxib
- ropivacaine
- rucaparib
- ruxolitinib
S
- scopolamine
- secobarbital
- sertraline
- sibutramine
- sirolimus
- sodium salicylate
- solifenacin
- sotalol
- sparfloxacin
- sparsentan
- spironolactone
- streptokinase
- streptomycin
- sulfasalazine
- sulfinpyrazone
- sulindac
T
- tacrine
- tacrolimus
- tafamidis
- tafasitamab
- tazemetostat
- telbivudine
- telmisartan
- temsirolimus
- tenecteplase
- tenofovir alafenamide
- tenofovir disoproxil
- teriflunomide
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- thioguanine
- thiopental
- ticagrelor
- ticlopidine
- tiludronate
- timolol
- timothy grass pollen allergen extract
- tinzaparin
- tirofiban
- tislelizumab
- tobramycin
- tofacitinib
- tolazamide
- tolbutamide
- tolmetin
- tolterodine
- toripalimab
- torsemide
- tositumomab
- tovorafenib
- trabectedin
- trandolapril
- tremelimumab
- treosulfan
- treprostinil
- triamcinolone
- triamcinolone ophthalmic
- triamterene
- trichlormethiazide
- trihexyphenidyl
- trospium
- trovafloxacin
- turmeric
U
V
- vadadustat
- valacyclovir
- valdecoxib
- valganciclovir
- valoctocogene roxaparvovec
- valproic acid
- valsartan
- vamorolone
- vancomycin
- varenicline
- vasopressin
- vemurafenib
- venlafaxine
- verapamil
- verteporfin
- vilazodone
- voclosporin
- vorapaxar
- voriconazole
- vortioxetine
W
Z
Acetaminophen/ibuprofen alcohol/food interactions
There are 3 alcohol/food interactions with acetaminophen / ibuprofen.
Acetaminophen/ibuprofen disease interactions
There are 14 disease interactions with acetaminophen / ibuprofen which include:
- alcoholism
- liver disease
- asthma
- fluid retention
- GI toxicity
- rash
- renal toxicities
- thrombosis
- PKU
- PKU
- anemia
- hepatotoxicity
- hyperkalemia
- platelet aggregation inhibition
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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