Acetaminophen/ibuprofen Interactions
There are 518 drugs known to interact with acetaminophen/ibuprofen, along with 14 disease interactions, and 3 alcohol/food interactions. Of the total drug interactions, 100 are major, 378 are moderate, and 40 are minor.
- View all 518 medications that may interact with acetaminophen/ibuprofen
- View acetaminophen/ibuprofen alcohol/food interactions (3)
- View acetaminophen/ibuprofen disease interactions (14)
Most frequently checked interactions
View interaction reports for acetaminophen / ibuprofen and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Adderall XR (amphetamine / dextroamphetamine)
- Advair Diskus (fluticasone / salmeterol)
- Afrin (oxymetazoline nasal)
- Alcohol (contained in alcoholic beverages) (ethanol)
- Aleve (naproxen)
- Aspercreme Maximum Strength Lidocaine Patch (lidocaine topical)
- Aspirin Low Strength (aspirin)
- Azo-Cranberry (cranberry)
- Benadryl (diphenhydramine)
- Celebrex (celecoxib)
- Cialis (tadalafil)
- Claritin (loratadine)
- Colace (docusate)
- CoQ10 (ubiquinone)
- Cymbalta (duloxetine)
- Dramamine (dimenhydrinate)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Imitrex (sumatriptan)
- Metoprolol Succinate ER (metoprolol)
- MiraLAX (polyethylene glycol 3350)
- Mounjaro (tirzepatide)
- Paracetamol (acetaminophen)
- Paxlovid (nirmatrelvir / ritonavir)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Vyvanse (lisdexamfetamine)
- Wellbutrin XL (bupropion)
- Zyrtec (cetirizine)
Acetaminophen/ibuprofen alcohol/food interactions
There are 3 alcohol/food interactions with acetaminophen / ibuprofen.
Acetaminophen/ibuprofen disease interactions
There are 14 disease interactions with acetaminophen / ibuprofen which include:
- alcoholism
- liver disease
- asthma
- fluid retention
- GI toxicity
- rash
- renal toxicities
- thrombosis
- PKU
- PKU
- anemia
- hepatotoxicity
- hyperkalemia
- platelet aggregation inhibition
Report options
More about acetaminophen / ibuprofen
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- Drug images
- Side effects
- Drug class: analgesic combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Paracetamol
Paracetamol (Panadol, Calpol, Alvedon) is a widely used over-the-counter painkiller and fever ...
Tylenol
Tylenol is a pain reliever and a fever reducer used to treat many conditions such as headaches ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Advil
Advil (ibuprofen) reduces fever, pain and inflammation caused by headaches, toothaches, arthritis ...
Aleve
Aleve is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. Learn ...
Naprosyn
Naprosyn (naproxen) is an anti-inflammatory drug used to treat pain and inflammation in arthritis ...
Ketoprofen
Ketoprofen systemic is used for back pain, fever, frozen shoulder, gout, acute, osteoarthritis ...
Oxycodone
Oxycodone is an opioid analgesic used to treat moderate to severe pain; it has a high potential for ...
Ibuprofen
Ibuprofen (Advil, Motrin) treats minor aches and pains caused by the common cold, headaches ...
Hydroxyzine
Hydroxyzine is an antihistamine used to treat itching, hives, and anxiety. It also acts as a ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
