Acetaminophen / ibuprofen Side Effects
Medically reviewed by Drugs.com. Last updated on Jan 31, 2022.
Applies to acetaminophen / ibuprofen: oral tablet
Use this medicine exactly as directed. An overdose of acetaminophen can damage your liver or cause death.
Ibuprofen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using ibuprofen, especially in older adults.
Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.
Get emergency medical help if you have signs of an allergic reaction (hives; difficulty breathing; swelling of your face, lips, tongue, or throat) or signs of a heart attack or stroke (chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg swelling, feeling short of breath).
In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.
Stop taking this medicine and call your doctor at once if you have:
swelling, rapid weight gain, feeling short of breath;
little or no urination;
loss of appetite, new or worsening stomach pain;
bloody or tarry stools;
coughing up blood or vomit that looks like coffee grounds; or
dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may be more likely, and you may have none at all.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.