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Zydone (acetaminophen / hydrocodone) Drug Interactions

A total of 1025 drugs are known to interact with Zydone (acetaminophen / hydrocodone).

  • 397 major drug interactions
  • 595 moderate drug interactions
  • 33 minor drug interactions

Show all medications in the database that may interact with Zydone (acetaminophen / hydrocodone).

Check for interactions with Zydone (acetaminophen / hydrocodone)

Type in a drug name and select a drug from the list.

Common medications checked in combination with Zydone (acetaminophen / hydrocodone)

  • Astelin (azelastine nasal)
  • clonazepam (Klonopin, Klonopin Wafer)
  • Crestor (rosuvastatin)
  • Cymbalta (duloxetine)
  • docusate (Colace, DOK, Dulcolax Stool Softener, Doc-Q-Lace, Surfak, DSS, Docusil, Docuprene, Calcium Stool Softener, Diocto, Colace Micro-Enema, Phillips Stool Softener, Doculase, Promolaxin, Surfak Stool Softener, DOS, Dioctocal, Ex-Lax Stool Softener, Silace, Enemeez Mini, Sulfolax, Dialose, DC-240, Kasof, Sulfalax Calcium, Modane Soft, Regulax SS, Dioeze, Aqualax, Dioctosoftez, Dioctyn, Dionex, Docu, Docu Soft, Docucal, Docusoft S, Calube, D-S Caps, Genasoft, Sur-Q-Lax, Doss-Relief, Fleet Sof-Lax Stool Softener, Correctol Softgel Extra Gentle, Therevac-SB, Octycine-100, Octycine-250, DocuSol, Kaopectate Stool Softener, Kao-Tin, Pedia-Lax Stool Softener, Pedia-Lax Liquid Stool Softener, Vacuant, DocuSol Kids)
  • furosemide (Lasix, Diaqua-2, Lo-Aqua)
  • hydrochlorothiazide (HydroDIURIL, Microzide, Esidrix, Oretic, Aquazide H, Hydro Par, Ezide, Carozide, Diaqua, Loqua)
  • meclizine (Antivert, Dramamine Less Drowsy, Bonine, Meclicot, Travel Sickness, Dramamine II, Dramamine All Day Less Drowsy, Travel-Ease, Sea-Calm, Antrizine, Medivert, D-Vert, Driminate II, Ru-Vert-M, Meni-D, Help I'm Nauseous, Motion-Time, Verticalm)
  • melatonin (Melatonin Time Release, Bio-Melatonin, SGard, Health Aid Melatonin, VesPro Melatonin)
  • Nexium (esomeprazole)
  • Percodan (aspirin / oxycodone)
  • Restasis (cyclosporine ophthalmic)
  • Rozerem (ramelteon)
  • simvastatin (Zocor, FloLipid)
  • Synthroid (levothyroxine)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Larapam SR, Tramedo, Ryzolt, GenRx Tramadol, ConZip, Zydol, Tramal SR, Tramahexal, Zamadol, Tramahexal SR, Zydol XL, Rybix ODT, Ultram ODT)
  • trazodone (Desyrel, Oleptro, Desyrel Dividose)
  • Vicoprofen (hydrocodone / ibuprofen)
  • Zofran (ondansetron)
  • zolpidem (Ambien, Ambien CR, Zolpimist, Intermezzo, Edluar)

Zydone (acetaminophen / hydrocodone) alcohol/food interactions

There is 1 alcohol/food interaction with Zydone (acetaminophen / hydrocodone)

Zydone (acetaminophen / hydrocodone) disease interactions

There are 19 disease interactions with Zydone (acetaminophen / hydrocodone) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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