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Norco (acetaminophen / hydrocodone) Drug Interactions

A total of 1018 drugs are known to interact with Norco (acetaminophen / hydrocodone).

  • 396 major drug interactions
  • 589 moderate drug interactions
  • 33 minor drug interactions

Show all medications in the database that may interact with Norco (acetaminophen / hydrocodone).

Check for interactions with Norco (acetaminophen / hydrocodone)

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Common medications checked in combination with Norco (acetaminophen / hydrocodone)

  • Advil (ibuprofen)
  • Aleve (naproxen)
  • Ambien (zolpidem)
  • aspirin (Aspir 81, Ecotrin, Acetylsalicylic Acid, Aspirin Low Strength, Bayer Aspirin, Aspir-Low, Ascriptin, Arthritis Pain, Fasprin, Ecotrin Adult Low Strength, Low Dose ASA, Bufferin, Aspiritab, Aspirin Lite Coat, Easprin, Bayer Children's Aspirin, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Bayer Aspirin Regimen, Aspirtab, Halfprin, Aspergum, Durlaza, Acuprin 81, Miniprin, Bufferin Low Dose, Empirin, Buffered Aspirin, Entercote, St. Joseph Aspirin, Ascriptin Enteric, Ecpirin, Bayer Women's Aspirin With Calcium, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Aspi-Cor, Medi-Seltzer, Sloprin, St. Joseph 81 mg Chewable Aspirin, ZORprin, Bayer Aspirin Extra Strength Plus, Buffex, Ecotrin Maximum Strength, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Bufferin Extra Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, Zero-Order Release, YSP Aspirin, Migralex, Heartline, Bayer Advanced Aspirin, Buffasal)
  • baclofen (Lioresal, Gablofen, Kemstro, Lioresal Intrathecal)
  • Benadryl (diphenhydramine)
  • clonazepam (Klonopin, Klonopin Wafer)
  • codeine
  • cyclobenzaprine (Flexeril, Amrix, Fexmid, Comfort Pac with Cyclobenzaprine)
  • Cymbalta (duloxetine)
  • Excedrin Migraine (acetaminophen / aspirin / caffeine)
  • Flexeril (cyclobenzaprine)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • ibuprofen (Advil, Motrin, IBU, Proprinal, Advil Liqui-Gels, Motrin IB, IBU-200, Nuprin, Advil Infant's Concentrated Drops, Children's Motrin, Advil Children's, Ibu-8, Ibuprofen PMR, Caldolor, Motrin Childrens, Motrin Migraine Pain, Addaprin, Ibu-4, Ibu-Tab, Rufen, Midol IB, A-G Profen, Childrens Ibuprofen Berry, Advil Migraine, Ibu-6, Motrin Infant Drops, NeoProfen, Genpril, Haltran, Menadol, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Levothyrox, Unithroid, Euthyrox, Levo-T, L Thyroxine Roche, Novothyrox, Levotabs, Oroxine, Eutroxsig, Tirosint-Sol, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • Lyrica (pregabalin)
  • meloxicam (Mobic, Vivlodex, Qmiiz ODT)
  • metformin (Glucophage, Glumetza, Glucophage XR, Riomet, Fortamet)
  • Motrin (ibuprofen)
  • naproxen (Aleve, Naprosyn, Naproxen Sodium DS, Anaprox, Naprelan, Anaprox-DS, Flanax Pain Reliever, EC-Naprosyn, Leader Naproxen Sodium, Aflaxen, All Day Pain Relief, Comfort Pac with Naproxen, Pamprin All Day Relief, Midol Extended Relief, All Day Relief)
  • Neurontin (gabapentin)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • Percocet (acetaminophen / oxycodone)
  • prednisone (Deltasone, Rayos, Sterapred DS, Sterapred, Prednicot, Meticorten, Liquid Pred, Orasone, Prednicen-M)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Tramedo, GenRx Tramadol, ConZip, Zydol, Ryzolt, Larapam SR, Tramahexal, Zamadol, Tramal SR, Tramahexal SR, Zydol XL, Rybix ODT, Rybix, Ultram ODT)
  • trazodone (Desyrel, Oleptro, Desyrel Dividose)
  • Tylenol (acetaminophen)
  • Valium (diazepam)
  • Vicodin (acetaminophen / hydrocodone)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zoloft (sertraline)

Norco (acetaminophen / hydrocodone) alcohol/food Interactions

There is 1 alcohol/food interaction with Norco (acetaminophen / hydrocodone)

Norco (acetaminophen / hydrocodone) disease Interactions

There are 19 disease interactions with Norco (acetaminophen / hydrocodone) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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