Acetaminophen/diphenhydramine/phenylephrine Interactions
There are 685 drugs known to interact with acetaminophen/diphenhydramine/phenylephrine, along with 15 disease interactions, and 3 alcohol/food interactions. Of the total drug interactions, 50 are major, 621 are moderate, and 14 are minor.
- View all 685 medications that may interact with acetaminophen/diphenhydramine/phenylephrine
- View acetaminophen/diphenhydramine/phenylephrine alcohol/food interactions (3)
- View acetaminophen/diphenhydramine/phenylephrine disease interactions (15)
Most frequently checked interactions
View interaction reports for acetaminophen / diphenhydramine / phenylephrine and the medicines listed below.
- Advil (ibuprofen)
- Advil (ibuprofen)
- Allegra (fexofenadine)
- Allegra (fexofenadine)
- Augmentin (amoxicillin / clavulanate)
- Augmentin (amoxicillin / clavulanate)
- Benadryl (diphenhydramine)
- Benadryl (diphenhydramine)
- Claritin-D (loratadine / pseudoephedrine)
- Claritin-D (loratadine / pseudoephedrine)
- Flexeril (cyclobenzaprine)
- Flexeril (cyclobenzaprine)
- Flonase (fluticasone nasal)
- Flonase (fluticasone nasal)
- Lantus (insulin glargine)
- Lantus (insulin glargine)
- Mucinex Fast-Max Severe Cold (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
- Mucinex Fast-Max Severe Cold (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
- Nitrostat (nitroglycerin)
- Nitrostat (nitroglycerin)
- Pamprin Multi-Symptom Menstrual Relief (acetaminophen / pamabrom / pyrilamine)
- Pamprin Multi-Symptom Menstrual Relief (acetaminophen / pamabrom / pyrilamine)
- Pepto-Bismol (bismuth subsalicylate)
- Pepto-Bismol (bismuth subsalicylate)
- ProAir HFA (albuterol)
- ProAir HFA (albuterol)
- Vitamin B12 (cyanocobalamin)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Vitamin D3 (cholecalciferol)
Acetaminophen/diphenhydramine/phenylephrine alcohol/food interactions
There are 3 alcohol/food interactions with acetaminophen / diphenhydramine / phenylephrine.
Acetaminophen/diphenhydramine/phenylephrine disease interactions
There are 15 disease interactions with acetaminophen / diphenhydramine / phenylephrine which include:
- alcoholism
- liver disease
- depression
- cardiovascular disease
- PKU
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- BPH
- diabetes
- glaucoma
Report options
More about acetaminophen / diphenhydramine / phenylephrine
- acetaminophen/diphenhydramine/phenylephrine consumer information
- Compare alternatives
- Reviews (5)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Chlorpheniramine
Chlorpheniramine is used for allergic reactions, allergic rhinitis, allergies, cold symptoms, food ...
Diphenhydramine
Diphenhydramine is an antihistamine used to treat sneezing, runny nose, itching, hives and other ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
