Acetaminophen/diphenhydramine/phenylephrine Interactions
There are 684 drugs known to interact with acetaminophen/diphenhydramine/phenylephrine, along with 15 disease interactions, and 3 alcohol/food interactions. Of the total drug interactions, 50 are major, 620 are moderate, and 14 are minor.
- View all 684 medications that may interact with acetaminophen/diphenhydramine/phenylephrine
- View acetaminophen/diphenhydramine/phenylephrine alcohol/food interactions (3)
- View acetaminophen/diphenhydramine/phenylephrine disease interactions (15)
Most frequently checked interactions
View interaction reports for acetaminophen / diphenhydramine / phenylephrine and the medicines listed below.
- 5-HTP (5-hydroxytryptophan)
- A+D (vitamin a & d topical)
- Abilify (aripiprazole)
- Acidophilus (lactobacillus acidophilus)
- Acidophilus Probiotic Blend (lactobacillus acidophilus)
- Advil (ibuprofen)
- Advil Cold and Sinus (ibuprofen / pseudoephedrine)
- Advil PM (diphenhydramine / ibuprofen)
- Afluria Quadrivalent (influenza virus vaccine, inactivated)
- Airborne (multivitamin with minerals)
- Alcohol (contained in alcoholic beverages) (ethanol)
- Allegra (fexofenadine)
- Augmentin (amoxicillin / clavulanate)
- Benadryl (diphenhydramine)
- Claritin-D (loratadine / pseudoephedrine)
- Flexeril (cyclobenzaprine)
- Flonase (fluticasone nasal)
- Lantus (insulin glargine)
- Mucinex Fast-Max Severe Cold (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
- Nitrostat (nitroglycerin)
- Pamprin Multi-Symptom Menstrual Relief (acetaminophen / pamabrom / pyrilamine)
- Pepto-Bismol (bismuth subsalicylate)
- ProAir HFA (albuterol)
- Probiotic Formula (bifidobacterium infantis / lactobacillus acidophilus)
- Promethazine DM (dextromethorphan / promethazine)
- Tylenol (acetaminophen)
- Tylenol Cold and Flu Severe Day & Night (acetaminophen / chlorpheniramine / dextromethorphan / guaifenesin / phenylephrine)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Xarelto (rivaroxaban)
Acetaminophen/diphenhydramine/phenylephrine alcohol/food interactions
There are 3 alcohol/food interactions with acetaminophen / diphenhydramine / phenylephrine.
Acetaminophen/diphenhydramine/phenylephrine disease interactions
There are 15 disease interactions with acetaminophen / diphenhydramine / phenylephrine which include:
- alcoholism
- liver disease
- depression
- cardiovascular disease
- PKU
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- BPH
- diabetes
- glaucoma
Report options
More about acetaminophen / diphenhydramine / phenylephrine
- acetaminophen/diphenhydramine/phenylephrine consumer information
- Compare alternatives
- Reviews (5)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Benadryl
Benadryl is an antihistamine and is used to treat sneezing, runny nose, itching and other ...
Promethazine DM
Promethazine DM is used for allergic rhinitis, cold symptoms, cough
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Banophen
Banophen is used for allergic reactions, allergic rhinitis, cold symptoms, cough, extrapyramidal ...
Benadryl Allergy
Benadryl Allergy is used for allergic reactions, allergic rhinitis, allergies, cold symptoms ...
Pseudoephedrine/triprolidine
Pseudoephedrine/triprolidine systemic is used for allergic rhinitis, cold symptoms
Echinacea
Echinacea systemic is used for cold symptoms, condylomata acuminata, herbal supplementation
Chlorpheniramine
Chlorpheniramine systemic is used for allergic reactions, allergic rhinitis, allergies, cold ...
Diphenhydramine
Diphenhydramine is an antihistamine used to treat sneezing, runny nose, itching, hives and other ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
