Acetaminophen/diphenhydramine/phenylephrine Interactions
There are 683 drugs known to interact with acetaminophen/diphenhydramine/phenylephrine, along with 15 disease interactions, and 3 alcohol/food interactions. Of the total drug interactions, 50 are major, 619 are moderate, and 14 are minor.
- View all 683 medications that may interact with acetaminophen/diphenhydramine/phenylephrine
- View acetaminophen/diphenhydramine/phenylephrine alcohol/food interactions (3)
- View acetaminophen/diphenhydramine/phenylephrine disease interactions (15)
Most frequently checked interactions
View interaction reports for acetaminophen / diphenhydramine / phenylephrine and the medicines listed below.
- 5-HTP (5-hydroxytryptophan)
- A+D (vitamin a & d topical)
- Abilify (aripiprazole)
- Acidophilus (lactobacillus acidophilus)
- Acidophilus Probiotic Blend (lactobacillus acidophilus)
- Advil (ibuprofen)
- Advil Cold and Sinus (ibuprofen / pseudoephedrine)
- Advil PM (diphenhydramine / ibuprofen)
- Afluria Quadrivalent (influenza virus vaccine, inactivated)
- Airborne (multivitamin with minerals)
- Alcohol (contained in alcoholic beverages) (ethanol)
- Alka-Seltzer Plus Maximum Strength Cold & Cough (acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine)
- Allegra (fexofenadine)
- Augmentin (amoxicillin / clavulanate)
- Benadryl (diphenhydramine)
- Flexeril (cyclobenzaprine)
- Flonase (fluticasone nasal)
- Lantus (insulin glargine)
- Mucinex Fast-Max Severe Cold (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
- Nitrostat (nitroglycerin)
- Pamprin Multi-Symptom Menstrual Relief (acetaminophen / pamabrom / pyrilamine)
- Pepto-Bismol (bismuth subsalicylate)
- ProAir HFA (albuterol)
- Probiotic Formula (bifidobacterium infantis / lactobacillus acidophilus)
- Promethazine DM (dextromethorphan / promethazine)
- Tylenol (acetaminophen)
- Tylenol Cold and Flu Severe Day & Night (acetaminophen / chlorpheniramine / dextromethorphan / guaifenesin / phenylephrine)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Xarelto (rivaroxaban)
Acetaminophen/diphenhydramine/phenylephrine alcohol/food interactions
There are 3 alcohol/food interactions with acetaminophen / diphenhydramine / phenylephrine.
Acetaminophen/diphenhydramine/phenylephrine disease interactions
There are 15 disease interactions with acetaminophen / diphenhydramine / phenylephrine which include:
- alcoholism
- liver disease
- depression
- cardiovascular disease
- PKU
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- BPH
- diabetes
- glaucoma
Report options
More about acetaminophen / diphenhydramine / phenylephrine
- acetaminophen/diphenhydramine/phenylephrine consumer information
- Compare alternatives
- Reviews (5)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
