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Zolpimist Dosage

Generic name: Zolpidem Tartrate 5mg
Dosage form: oral spray, metered

Medically reviewed on March 21, 2018.

Dosage in Adults

Use the lowest effective dose for the patient. The recommended initial dose is 5 mg for women and either 5 or 10 mg for men, taken only once per night immediately before bedtime with at least 7-8 hours remaining before the planned time of awakening. If the 5 mg dose is not effective, the dose can be increased to 10 mg. In some patients, the higher morning blood levels following use of the 10 mg dose increase the risk of next day impairment of driving and other activities that require full alertness [see Warnings and Precautions (5.1)]. The total dose of Zolpimist (zolpidem tartrate) Oral Spray should not exceed 10 mg once daily immediately before bedtime.

The recommended initial doses for women and men are different because zolpidem clearance is lower in women.

Special Populations

Elderly or debilitated patients may be especially sensitive to the effects of zolpidem tartrate. Patients with hepatic insufficiency do not clear the drug as rapidly as normal subjects. The recommended dose of Zolpimist (zolpidem tartrate) Oral Spray in both of these patient populations is 5 mg once daily immediately before bedtime [see Warnings and Precautions (5.1); Use in Specific Populations (8.5)].

Use with CNS Depressants

Dosage adjustment may be necessary when Zolpimist (zolpidem tartrate) Oral Spray is combined with other CNS-depressant drugs because of the potentially additive effects [see Warnings and Precautions (5.1)].


Zolpimist (zolpidem tartrate) Oral Spray is packaged in a child-resistant container. For detailed instructions on how to use zolpidem tartrate (Zolpimist) Oral Spray, refer to the Patient Instructions for Use (following the Medication Guide). Zolpimist (zolpidem tartrate) Oral Spray must be primed before it is used for the first time. To prime, patients should be told to point the black spray opening away from their face and other people and spray 5 times. For administration, the child- resistant container should be held upright with the black spray opening pointed directly into the mouth. The patient should fully press down on the pump to make sure a full dose (5 mg) of Zolpimist (zolpidem tartrate) Oral Spray is sprayed directly into the mouth over the tongue. If a 10 mg dose is prescribed, a second spray should be administered.

If the patient does not use Zolpimist (zolpidem tartrate) Oral Spray for at least 14 days, it must be primed again with 1 spray. The patient should be referred to the Patient Instructions for Use included at the end of the Medication Guide.

The effect of Zolpimist (zolpidem tartrate) Oral Spray may be slowed by ingestion with or immediately after a meal.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.