Applies to the following strengths: 40 mg; 80 mg
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Tardive Dyskinesia
-Initial Dose: 40 mg orally once a day
-Maintenance Dose: Increase to 80 mg orally once a day after one week at the initial dose; however, continuation of the initial dose may be considered for some patients.
Comments: Administer with or without food.
Use: Treatment of tardive dyskinesia.
Renal Dose Adjustments
-Mild to Moderate Renal Impairment (CrCl 30 to 90 mL/min): No adjustment recommended.
-Severe Renal Impairment (CrCl less than 30 mL/min): Not recommended.
Liver Dose Adjustments
-Moderate to Severe Hepatic Impairment (Child-Pugh score 7 to 15): 40 mg orally once a day.
CYP450 2D6 POOR METABOLIZERS: Consider reducing the dose based on tolerability.
CONCOMITANT USE WITH MONOAMINE OXIDASE INHIBITORS (MAOIs): Avoid concomitant use.
CONCOMITANT USE WITH STRONG CYP450 INDUCERS/INHIBITORS:
-CYP450 3A4 Inducers: Not recommended.
-CYP450 3A4 Inhibitors: 40 mg orally once a day.
-CYP450 2D6 Inhibitors: Consider reducing the dose based on tolerability.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available.
-Store at 20 to 25 degrees Celsius (68 to 77 degrees Fahrenheit); excursions permitted to 15 to 30 degrees Celsius (59 to 86 degrees Fahrenheit).
-This drug and its active metabolite ([+]-alpha-HTBZ) have no appreciable binding affinity for dopaminergic, serotonergic, adrenergic, histaminergic, or muscarinic receptors.
-Overdosage: No specific antidotes are known, and there is no information regarding overdose symptoms from clinical trials. Provide supportive care and consider the possibility of multiple drug involvement in managing overdose.
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- Drug class: VMAT2 inhibitors
Other brands: Ingrezza