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Synjardy Dosage

Generic name: EMPAGLIFLOZIN 5mg, METFORMIN HYDROCHLORIDE 500mg
Dosage form: tablet
Drug class: Antidiabetic combinations

Medically reviewed by Drugs.com. Last updated on Mar 24, 2022.

Prior to Initiation of SYNJARDY

Recommended Dosage and Administration

  • Individualize the starting dose of SYNJARDY based on the patient's current regimen:
    • In patients on metformin HCl, switch to SYNJARDY containing empagliflozin 5 mg with a similar total daily dose of metformin HCl;
    • In patients on empagliflozin, switch to SYNJARDY containing metformin HCl 500 mg with a similar total daily dose of empagliflozin;
    • In patients already treated with empagliflozin and metformin HCl, switch to SYNJARDY containing the same total daily doses of each component.
  • Monitor effectiveness and tolerability, and adjust dosing as appropriate, not to exceed the maximum recommended daily dose of empagliflozin 25 mg and metformin HCl 2000 mg.
  • Take SYNJARDY twice daily with meals; with gradual dose escalation to reduce the gastrointestinal side effects due to metformin.

Dosage Recommendations in Patients with Renal Impairment

Discontinuation for Iodinated Contrast Imaging Procedures

Discontinue SYNJARDY at the time of, or prior to, an iodinated contrast imaging procedure in patients with an eGFR less than 60 mL/min/1.73 m2; in patients with a history of liver disease, alcoholism or heart failure; or in patients who will be administered intra-arterial iodinated contrast. Re-evaluate eGFR 48 hours after the imaging procedure; restart SYNJARDY if renal function is stable [see Warnings and Precautions (5.1)].

Frequently asked questions

Further information

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