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Pertuzumab Dosage

Medically reviewed by Drugs.com. Last updated on May 4, 2023.

Applies to the following strengths: 420 mg/14 mL

Usual Adult Dose for Breast Cancer

METASTATIC BREAST CANCER (MBC):
840 mg IV over 60 minutes, followed by 420 mg IV over 30 to 60 minutes every 3 weeks

NEOADJUVANT TREATMENT OF BREAST CANCER:
840 mg IV over 60 minutes, followed by 420 mg IV every 3 weeks over 30 to 60 minutes

1) Four preoperative cycles of this drug in combination with trastuzumab and docetaxel followed by 3 postoperative cycles of fluorouracil, epirubicin, and cyclophosphamide (FEC).
2) Three or 4 preoperative cycles of FEC alone followed by 3 or 4 preoperative cycles of this drug in combination with docetaxel and trastuzumab.
3) Six preoperative cycles of this drug in combination with docetaxel, carboplatin, and trastuzumab (TCH).
4) Four preoperative cycles of dose-dense doxorubicin and cyclophosphamide (ddAC) alone followed by 4 preoperative cycles of this drug in combination with paclitaxel and trastuzumab.

Comments:

Uses:
1) In combination with trastuzumab and docetaxel for treatment of patients with HER2-positive metastatic breast cancer (MBC) who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease
2) In combination with trastuzumab and chemotherapy as:

Renal Dose Adjustments

Mild to moderate renal dysfunction: No adjustment recommended
Severe renal dysfunction: Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments


DOSE MODIFICATIONS FOR LEFT VENTRICULAR EJECTION FRACTION (LVEF) DYSFUNCTION:
1) Metastatic Breast Cancer (MBC):
2) Early Breast Cancer:

Precautions

US BOXED WARNINGS:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:

General:

Monitoring:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.