Medically reviewed on October 14, 2016.
Applies to the following strengths: 0.25 mg/5 mL; 0.075 mg/1.5 mL
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Nausea/Vomiting - Chemotherapy Induced
Oral: 0.5 mg orally administered approximately 1 hour prior to the start of chemotherapy
Uses: Moderately emetogenic cancer chemotherapy: Prevention of acute nausea and vomiting associated with initial and repeat courses.
Parenteral: 0.25 mg IV as a single dose 30 minutes before the start of chemotherapy
Uses: Prevention of acute nausea and vomiting in adults associated with initial and repeat courses of moderately and highly emetogenic cancer chemotherapy.
Usual Adult Dose for Nausea/Vomiting - Postoperative
Parenteral: 0.075 mg IV as a single dose immediately before induction of anesthesia
Uses: Prevention of postoperative nausea and vomiting (PONV) in adults for up to 24 hours following surgery. Efficacy beyond 24 hours has not been determined.
Usual Pediatric Dose for Nausea/Vomiting - Chemotherapy Induced
Parenteral: 20 mcg/kg IV (maximum 1.5 mg x 1) infused over 15 minutes beginning 30 minutes before the start of chemotherapy
Uses: Prevention of acute nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including highly emetogenic cancer chemotherapy in patients 1 month to less than 17 years of age.
Renal Dose Adjustments
No adjustment recommended
Liver Dose Adjustments
No adjustment recommended
-No dose adjustment is required in elderly patients.
-Experience with repeat dosing within a course of multi-day chemotherapy is limited.
This drug may increase large bowel transit time; therefore, it is recommended to monitor patients with a history of constipation or signs of subacute intestinal obstruction following administration.
Safety and effectiveness have not been established in patients younger than 18 years.
Data not available
-This drug may be taken without regard to meals.
-This drug should be infused intravenously over 30 seconds.
-The IV infusion line should be flushed with normal saline before and after administration of this drug.
-This drug should be stored below 25 degrees Celsius and protected from light.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about palonosetron
- Palonosetron Side Effects
- During Pregnancy
- Drug Interactions
- Pricing & Coupons
- En Español
- 2 Reviews
- Drug class: 5HT3 receptor antagonists
Other brands: Aloxi
- Palonosetron Hydrochloride (AHFS Monograph)
- Palonosetron Hydrochloride Injection (FDA)
- Palonosetron (Wolters Kluwer)