Applies to the following strengths: 0.25 mg/5 mL; 0.075 mg/1.5 mL
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Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Nausea/Vomiting - Chemotherapy Induced
Oral: 0.5 mg orally administered approximately 1 hour prior to the start of chemotherapy
Uses: Moderately emetogenic cancer chemotherapy: Prevention of acute nausea and vomiting associated with initial and repeat courses.
Parenteral: 0.25 mg IV as a single dose 30 minutes before the start of chemotherapy
Uses: Prevention of acute nausea and vomiting in adults associated with initial and repeat courses of moderately and highly emetogenic cancer chemotherapy.
Usual Adult Dose for Nausea/Vomiting - Postoperative
Parenteral: 0.075 mg IV as a single dose immediately before induction of anesthesia
Uses: Prevention of postoperative nausea and vomiting (PONV) in adults for up to 24 hours following surgery. Efficacy beyond 24 hours has not been determined.
Usual Pediatric Dose for Nausea/Vomiting - Chemotherapy Induced
Parenteral: 20 mcg/kg IV (maximum 1.5 mg x 1) infused over 15 minutes beginning 30 minutes before the start of chemotherapy
Uses: Prevention of acute nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including highly emetogenic cancer chemotherapy in patients 1 month to less than 17 years of age.
Renal Dose Adjustments
No adjustment recommended
Liver Dose Adjustments
No adjustment recommended
-No dose adjustment is required in elderly patients.
-Experience with repeat dosing within a course of multi-day chemotherapy is limited.
This drug may increase large bowel transit time; therefore, it is recommended to monitor patients with a history of constipation or signs of subacute intestinal obstruction following administration.
Safety and effectiveness have not been established in patients younger than 18 years.
Data not available
-This drug may be taken without regard to meals.
-This drug should be infused intravenously over 30 seconds.
-The IV infusion line should be flushed with normal saline before and after administration of this drug.
-This drug should be stored below 25 degrees Celsius and protected from light.
More about palonosetron
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- Dosage Information
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- Drug class: 5HT3 receptor antagonists
Other brands: Aloxi
- Palonosetron Hydrochloride (AHFS Monograph)
- Palonosetron Hydrochloride Injection (FDA)
- Palonosetron (Wolters Kluwer)