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Palonosetron Side Effects

Medically reviewed by Last updated on Dec 28, 2022.

Applies to palonosetron: intravenous solution.

Serious side effects of Palonosetron

Along with its needed effects, palonosetron may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking palonosetron:

Less common


Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking palonosetron:

Symptoms of overdose

Other side effects of Palonosetron

Some side effects of palonosetron may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to palonosetron: intravenous solution, oral capsule.


The most commonly reported side effects included headache, constipation, diarrhea, and dizziness.[Ref]


Common (1% to 10%): Bradycardia/sinus bradycardia, electrocardiogram QTc prolongation, hypotension, nonsustained tachycardia/tachycardia

Uncommon (0.1% to 1%): Atrioventricular (AV) block first degree, AV block second degree, conduction disorder, extrasystoles, hypertension, myocardial ischemia, sinus arrhythmia, sinus tachycardia, supraventricular extrasystoles, vein discoloration, vein distended

Frequency not reported: Arrhythmia, blood pressure decreased, ECG T wave amplitude decreased, generalized edema, hot flash, ventricular extrasystoles

Postmarketing reports: Shock[Ref]


Common (1% to 10%): Constipation, diarrhea, flatulence

Uncommon (0.1% to 1%): Abdominal pain, abdominal pain upper, dry mouth, dyspepsia, nausea

Frequency not reported: Intestinal hypomobility, salivary hypersecretion[Ref]


Common (1% to 10%): Asthenia, weakness

Uncommon (0.1% to 1%): Fatigue, feeling hot, motion sickness, pain, pyrexia, tinnitus

Frequency not reported: Chills, fever[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache

Uncommon (0.1% to 1%): Dyskinesia, hypersomnia, paresthesia, peripheral sensory neuropathy, somnolence[Ref]


Common (1% to 10%): Increased ALT, increased AST

Uncommon (0.1% to 1%): Blood bilirubin increased, elevated transaminases, hyperbilirubinemia

Frequency not reported: Hepatic enzymes increased, transient, asymptomatic increases in AST and/or ALT and bilirubin[Ref]


Common (1% to 10%): Hyperkalemia

Uncommon (0.1% to 1%): Anorexia, appetite decreased, hyperglycemia, hypocalcemia, hypokalemia, metabolic disorders

Frequency not reported: Electrolyte fluctuations, metabolic acidosis[Ref]


Common (1% to 10%): Pruritus

Uncommon (0.1% to 1%): Allergic dermatitis, pruritic rash, skin disorder, urticaria[Ref]


Common (1% to 10%): Anxiety

Uncommon (0.1% to 1%): Euphoric mood, insomnia[Ref]


Common (1% to 10%): Urinary retention

Uncommon (0.1% to 1%): Glycosuria[Ref]


Uncommon (0.1% to 1%): Cough, dyspnea, epistaxis, hiccups

Frequency not reported: Hypoventilation, laryngospasm[Ref]


Uncommon (0.1% to 1%): Amblyopia, eye irritation, eye swelling[Ref]


Uncommon (0.1% to 1%): Infusion site pain, infusion site reaction

Very rare (less than 0.01%): Injection site reaction

Frequency not reported: Injection site burning, injection site discomfort, injection site induration, injection site pain[Ref]


Uncommon (0.1% to 1%): Arthralgia, myalgia[Ref]


Very rare (less than 0.01%): Hypersensitivity reactions

Frequency not reported: Anaphylactic shock, anaphylaxis[Ref]


Frequency not reported: Platelet count decreased[Ref]


Uncommon (0.1% to 1%): Influenza-like illness

Frequency not reported: Flu-like syndrome[Ref]


1. Product Information. Aloxi (palonosetron). MGI Pharma Inc. 2003.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.