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Mibefradil Dosage

Applies to the following strengths: 50 mg; 100 mg

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose: 50 mg orally once a day with or without food.
Maintenance dose: The initial dose may be titrated upward to 100 mg orally once a day as needed and tolerated.

Usual Adult Dose for Angina Pectoris

Initial dose: 50 mg orally once a day with or without food.
Maintenance dose: The initial dose may be titrated upward to 100 mg orally once a day as needed and tolerated.

Liver Dose Adjustments

No clinically relevant changes in the pharmacokinetic disposition of mibefradil have been observed in patients with liver disease. However, because this drug is completely metabolized by the liver and eliminated by the biliary system, caution is recommended when using this drug or advancing doses in this patient with liver disease. In general, periodic monitoring of the heart rate and blood pressure is recommended, particularly in patients with severe liver disease.

Dialysis

Be cognizant of the increased risk of hypotension if this drug is given too soon after hemodialysis sessions. On the days this patient is dialyzed, it is recommended that mibefradil be given at some time after hemodialysis when the patient is hemodynamically stable.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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