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Methyclothiazide / Reserpine Dosage

Applies to the following strengths: 2.5 mg-0.1 mg

Usual Adult Dose for Hypertension

Initial dose: 1 tablet orally once a day.
Maintenance dose: 1 to 2 tablets orally once a day.

Renal Dose Adjustments

Methyclothiazide is generally not effective in patients with creatine clearance less than 25 mL/min. Methyclothiazide should be used with caution in patients with severe renal disease. The elimination half-life of reserpine may be significantly increased in patients with renal insufficiency, therefore reserpine is not recommended in patients with renal dysfunction.

Liver Dose Adjustments

Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.

Dose Adjustments

The dose may be adjusted after 1 to 2 weeks.


Reserpine is not dialyzable.

Other Comments

The maximum recommended dose is 2 tablets orally once a day.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.