Magnesium Sulfate / Potassium Sulfate / Sodium Sulfate Dosage
Applies to the following strength(s): 1.6 g-3.13 g-17.5 g/177 mL
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Bowel Preparation
Magnesium/potassium/sodium sulfates bowel prep kit should be taken as a split-dose oral regimen.
The dose for colon cleansing requires administration of two bottles of magnesium/potassium/sodium sulfates bowel prep kit. Each bottle is administered as 16 ounces of diluted magnesium/potassium/sodium sulfates solution with an additional 1 quart of water taken orally. The total volume of liquid required for colon cleansing (using 2 bottles) is 3 quarts (approximately 2.8 L) taken orally prior to the colonoscopy in the following way:
Split-Dose (Two-Day) Regimen
Day prior to colonoscopy:
A light breakfast may be consumed, or have only clear liquids on the day before the colonoscopy. Nothing should be eaten for dinner. Avoid red and purple liquids, milk, and alcoholic beverages. Early in the evening prior to colonoscopy: pour the contents of 1 bottle of magnesium/potassium/sodium sulfates bowel prep kit into the mixing container provided. Fill the container with water to the 16 oz fill line, and drink the entire amount. Drink two additional containers filled to the 16 oz line with water over the next hour.
Day of colonoscopy:
Have only clear liquids until after the colonoscopy. Avoid red and purple liquids, milk, and alcoholic beverages. The morning of colonoscopy (10 to 12 hours after the evening dose): pour the contents of the second bottle of magnesium/potassium/sodium sulfates bowel prep into the mixing container provided. Fill the container with water to the 16 ounce fill line, and drink the entire amount. Drink two additional containers filled to the 16 oz line with water over the next hour.
Complete all magnesium/potassium/sodium sulfates bowel prep and required water at least two hours prior to colonoscopy.
Renal Dose Adjustments
Caution should be exercised when prescribing magnesium/potassium/sodium sulfates for patients with impaired renal function or patients taking concomitant medications that may affect renal function (such as diuretics, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, or nonsteroidal anti-inflammatory drugs). These patients should be advised of the importance of adequate hydration, and baseline and postcolonoscopy laboratory tests (electrolytes, creatinine, and BUN) may need to be performed in these patients.
Liver Dose Adjustments
Data not available
Geriatric patients may be dosed as adults; however, they reported more vomiting when magnesium/potassium/sodium sulfates bowel prep kit was given as a one-day preparation.
Each bottle must be diluted with water to a final volume of 16 oz and ingestion of additional water as recommended is important to patient tolerance. Direct ingestion of the undiluted solution may increase the risk of nausea, vomiting, dehydration, and electrolyte disturbances.
Oral medication administered within one hour of the start of each magnesium/potassium/sodium sulfates bowel prep kit dose may be flushed from the gastrointestinal tract, and the medication may not be absorbed properly.
Safety and effectiveness have not been established in pediatric patients (less than 18 years old).
Data not available
Patients undergoing a colonoscopy procedure should adequately hydrate before, during, and after the use of colon cleansing products. Patients should not take a colon cleansing product within 7 days of previous administration. No additional enema or laxative is required, and patients should be advised not to take additional products. Timing of all doses should be determined by the individual product manufacturer or a health care provider. If a patient develops significant vomiting or signs of dehydration after taking magnesium/potassium/sodium sulfates prep kit, consider performing postcolonoscopy lab tests (electrolytes, creatinine, and BUN). Fluid and electrolyte disturbances can lead to serious adverse events including cardiac arrhythmias, seizures and renal impairment.
Any of the following liquids may be consumed the day before and the day of the colonoscopy: water, strained fruit juices (without pulp), including apple, orange, white grape, or white cranberry, limeade or lemonade, coffee or tea (without dairy or nondairy creamer), chicken broth, or gelatin desserts without added fruit or topping (no red or purple).
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