Magnesium Sulfate / Potassium Sulfate / Sodium Sulfate Dosage
Medically reviewed by Drugs.com. Last updated on Jul 28, 2025.
Applies to the following strengths: 1.6 g-3.13 g-17.5 g/177 mL
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Bowel Preparation
Split-Dose Regimen (Preferred Method):
- Dose 1: 1.6 grams magnesium sulfate-3.13 grams potassium sulfate-17.5 grams sodium sulfate (per 6-ounce bottle) orally ONCE in the evening before the colonoscopy, followed by 32 ounces of water orally within the next hour
- Dose 2: 1.6 grams magnesium sulfate-3.13 grams potassium sulfate-17.5 grams sodium sulfate (per 6-ounce bottle) orally ONCE the day of the colonoscopy, followed by 32 ounces of water orally within the next hour
Comments:
- Note: This drug should be diluted with 16 ounces of cool water prior to administration.
- Patients may consume a light breakfast or clear liquids on Day 1 (e.g., no solid foods).
- Dose 2 should be administered approximately 10 to 12 hours after Dose 1; dosing should be completed at least 2 hours before the colonoscopy.
- Patients should consume only clear liquids (e.g., no solid food or dairy) up until 2 hours before the time of the colonoscopy.
- Those who experience severe bloating, distention, or abdominal pain may delay the second dose until the symptoms resolve.
Use: Cleansing of the colon as a preparation for colonoscopy
Usual Pediatric Dose for Bowel Preparation
12 years and older:
Split-Dose Regimen (Preferred Method):
- Dose 1: 1.2 grams magnesium sulfate-2.35 grams potassium sulfate-13.13 grams sodium sulfate (per 4.5-ounce bottle) orally ONCE in the evening before the colonoscopy, followed by 24 ounces of water orally within the next hour
- Dose 2: 1.2 grams magnesium sulfate-2.35 grams potassium sulfate-13.13 grams sodium sulfate (per 4.5-ounce bottle) orally ONCE the day of the colonoscopy, followed by 24 ounces of water orally within the next hour
Comments:
- Note: This drug should be diluted with 12 ounces of cool water prior to administration.
- Patients may consume a light breakfast or clear liquids on Day 1 (e.g., no solid foods).
- Dose 2 should be administered approximately 10 to 12 hours after Dose 1; dosing should be completed at least 2 hours before the colonoscopy.
- Patients should consume only clear liquids (e.g., no solid food or dairy) up until 2 hours before the time of the colonoscopy.
- Those who experience severe bloating, distention, or abdominal pain may delay the second dose until the symptoms resolve.
Use: Cleansing of the colon as a preparation for colonoscopy
Renal Dose Adjustments
Renal dysfunction and/or patients taking concomitant agents that may affect renal function:
Use with caution; patients should be advised regarding adequate hydration, and baseline and pos-colonoscopy tests should be considered (e.g., blood urea nitrogen [BUN], creatinine, electrolytes).
Liver Dose Adjustments
Data not available
Precautions
CONTRAINDICATIONS:
- Hypersensitivity to any/all the active components or to any of the ingredients
- Patients with bowel perforation
- Patients with gastric retention
- Patients with gastrointestinal obstruction or ileus
- Patients with toxic colitis/megacolon
Safety and efficacy have not been established in patients younger than 12 years; this drug is not recommended for use in these patients.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- Once reconstituted, this drug should be consumed immediately.
- Solid food, milk, red/purple drinks, and/or alcohol should be avoided during use.
- Additional oral medications should not be taken within an hour of taking this drug; fluoroquinolone or tetracycline antibiotics, chlorpromazine, digoxin, iron, and/or penicillamine should be taken at least 2 hours before OR 6 hours after administration of this drug.
- Additional laxative use should be avoided.
Reconstitution/preparation techniques:
- Oral solutions should be diluted prior to administration; the manufacturer product information should be consulted for further details.
General:
- Limitation of use: This drug should not be used as a routine laxative.
Monitoring:
- METABOLIC: Consider baseline and post-colonoscopy electrolyte monitoring in patients with renal dysfunction
- RENAL: Consider baseline and post-colonoscopy blood urea nitrogen and creatinine level monitoring in patients with renal dysfunction
Patient advice:
- Patients should be instructed to closely follow their healthcare providers' instructions regarding bowel preparation.
- Advise patients to remain adequately hydrated while using this drug.
- Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.
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Patient resources
- Magnesium sulfate, potassium sulfate, and sodium sulfate drug information
- Sodium sulfate, potassium sulfate, and magnesium sulfate (Advanced Reading)
- Sodium Sulfate, Potassium Sulfate, and Magnesium Sulfate
Other brands
Suprep Bowel Prep Kit, ColPrep Kit
Professional resources
Other brands
Suprep Bowel Prep Kit, ColPrep Kit
Related treatment guides
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.