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Lo Simpesse Dosage

Generic name: LEVONORGESTREL 0.1mg, ETHINYL ESTRADIOL 0.02mg; ETHINYL ESTRADIOL 0.01mg
Dosage form: tablets

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Medically reviewed on August 19, 2017.

Take one tablet by mouth at the same time every day. The dosage of Lo Simpesse is one light pink tablet containing levonorgestrel and ethinyl estradiol daily for 84 consecutive days, followed by one light blue ethinyl estradiol tablet for 7 days. To achieve maximum contraceptive effectiveness, Lo Simpesse must be taken exactly as directed and at intervals not exceeding 24 hours.

Instruct the patient to begin taking Lo Simpesse on the first Sunday after the onset of menstruation. If menstruation begins on a Sunday, the first light pink tablet is taken that day. One light pink tablet should be taken daily for 84 consecutive days, followed by one light blue tablet for 7 consecutive days. A non-hormonal back-up method of contraception (such as condoms or spermicide) should be used until a light pink tablet has been taken daily for 7 consecutive days. A scheduled period should occur during the 7 days that the light blue tablets are taken.

Begin the next and all subsequent 91-day cycles without interruption on the same day of the week (Sunday) on which the patient began her first dose of Lo Simpesse, following the same schedule: 84 days taking a light pink tablet followed by 7 days taking a light blue tablet. If the patient does not immediately start her next pill pack, she should protect herself from pregnancy by using a non-hormonal back-up method of contraception until she has taken a light pink tablet daily for 7 consecutive days.

If unscheduled spotting or bleeding occurs, instruct the patient to continue on the same regimen. If the bleeding is persistent or prolonged, advise the patient to consult her healthcare provider.

For patient instructions regarding missed pills, see PATIENT COUNSELING INFORMATION (17.2).

For postpartum women who are not breastfeeding, start Lo Simpesse no earlier than four to six weeks postpartum. If the patient starts on Lo Simpesse postpartum and has not yet had a period, evaluate for possible pregnancy, and instruct her to use an additional method of contraception until she has taken a light pink tablet for 7 consecutive days.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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