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Twirla Patch

Generic name: ethinyl estradiol and levonorgestrel (transdermal) [ ETH-in-ill-ess-tra-DYE-ol-and-LEE-vo-nor-JESS-trel ]
Brand name: Twirla
Drug class: Contraceptives

Medically reviewed by Judith Stewart, BPharm. Last updated on Feb 5, 2024.

What is Twirla?

Twirla patches contain a combination of two female hormones, ethinyl estradiol and levonorgestrel.

Twirla is a prescription medicine used as birth control to prevent pregnancy.

Twirla is for use by women with a BMI less than 30 kg/m2 who can become pregnant. Twirla patches have been shown to have reduced effectiveness in women with a BMI in the range 25 to 30 kg/m2.


You should not use Twirla if you have: uncontrolled high blood pressure, heart disease, coronary artery disease, health problems caused by diabetes (such as damage to your kidneys, eyes, nerves, or blood vessels), undiagnosed vaginal bleeding, liver disease or liver cancer, severe migraine headaches, if you also take certain hepatitis C medication, if you will have major surgery, if you smoke and are over 35, or if you have ever had a heart attack, a stroke, a blood clot, jaundice caused by pregnancy or this medicine, or cancer of the breast, uterus/cervix, or vagina.

Using Twirla can increase your risk of blood clots, stroke, or heart attack (especially if you smoke). You should not use this medicine if you smoke and are over 35 years old.

Before taking this medicine

Using Twirla can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, or if you are overweight

Smoking can greatly increase your risk of blood clots, stroke, or heart attack. Your risk increases the older you are and the more you smoke. You should not use Twirla patches if you smoke and are over 35 years old.

Your risk of serious blood clot may be higher with the use of birth control skin patches than with the use of birth control pills.

You should not use Twirla if you have:

To make sure Twirla patches are safe for you, tell your doctor if you have ever had

Do not use this medicine if you are pregnant. You may need to have a negative pregnancy test before using Twirla. Tell your doctor if you think you may be pregnant.

Ethinyl estradiol and levonorgestrel can slow breast milk production. You should not breastfeed while using this medicine.

How should I use Twirla?

Use Twirla exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Do not wear more than one skin patch at a time. Never cut a skin patch.

Apply a new Twirla skin patch every 7 days for 3 weeks in a row (21 days). Change your patch on the same day of the week, and wear each patch for 7 full days. On Day 22, remove the patch and wait 7 days before applying a new patch. Your patch-free week should not be longer than 7 days.

Apply the Twirla patch to clean, dry skin that is not broken or irritated and won't be rubbed by tight clothing (such as a waistband).

You may need to use back-up birth control (such as a condom/diaphragm with spermicide) when you first start using this medicine, or if a patch has become loose or has been off for longer than 1 day. Read and carefully follow all instructions about what to do if a patch gets loose or falls off, or if you forget to change your patch on time.

If you need major surgery or will be on long-term bed rest, do not use wear a skin patch for at least 4 weeks ahead of time and 2 weeks afterward.

You may have breakthrough bleeding, especially during the first 3 months. Tell your doctor if this bleeding is very heavy, or if you miss 2 or more regular periods.

Store Twirla patches at room temperature away from moisture and heat. Do not freeze or refrigerate. Keep each patch in its foil pouch until you are ready to apply it.

After removing a skin patch fold it in half, sticky side in, and throw it away in a place where children and pets cannot get to it. Do not flush a used patch down the toilet.

Dosing information

Twirla patches are used in a 28-day (four-week) cycle. A new patch is applied and worn for seven days for three consecutive weeks (Weeks 1, 2, and 3). No Twirla patch is worn during Week 4 (the patch-free week), when withdrawal bleeding is expected.

On the day after Week 4 ends, a new 28-day cycle is started by applying a new Twirla patch. Under no circumstances should there be more than a 7-day patch-free interval between each 28 day dosing cycle.

What happens if I miss a dose?

During your patch-free week, do not go without wearing a patch for longer than 7 days. Missing a dose increases your risk of becoming pregnant and you may need to use back-up birth control. Call your doctor if you miss a period for 2 months in a row.

If you forget to apply a Twirla patch at the start of a new cycle:

If you forget to change your patch during the 3-week wearing time:

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What to avoid

Do not smoke while using Twirla patches, especially if you are older than 35 years of age.

Grapefruit may interact with ethinyl estradiol and levonorgestrel and lead to unwanted side effects. Avoid the use of grapefruit products.

This medicine may cause darkening of your facial skin (chloasma), especially if you've ever had chloasma during a pregnancy. Avoid sunlight or tanning beds. Use sunscreen (SPF 30 or higher) when you are outdoors.

Avoid applying makeup, lotions, powders, or oils to the skin where you apply a skin patch.

Twirla side effects

Get emergency medical help if you have signs of an allergic reaction to Twirla: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

Common Twirla side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Twirla?

Many drugs can interact with ethinyl estradiol and levonorgestrel, and some drugs can make hormonal birth control less effective, which may result in pregnancy. Tell your doctor about all your other medicines, especially:

This list is not complete and many Other drugs may interact with ethinyl estradiol and levonorgestrel. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Popular FAQ

Twirla and Xulane are weekly birth control patches that are used to prevent pregnancy. They are both combination products containing an estrogen and progestin, however, the products contain different progestins and have slight differences in their appearance, efficacy and side effects profile. Continue reading

Birth control patches, such as Twirla, are a highly effective form of birth control. Birth control patches are as effective as birth control pills (oral contraceptives) and vaginal contraceptive rings.

Twirla has been shown to have reduced effectiveness in women with a BMI ≥ 25 kg/m2, which means it is less effective in women who are overweight. Continue reading

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and Twirla only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.