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Levonorgestrel Dosage

Applies to the following strength(s): 36 mg0.75 mg1.5 mg52 mg13.5 mg

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Contraception

Intrauterine System (IUS):
-Insert 1 IUS (13.5 mg or 52 mg) during the first 7 days of the menstrual cycle or immediately after a first trimester miscarriage or abortion
-Duration of therapy: Mirena(R): 5 years; Liletta(R) and Skyla(R): 3 years

Comments:
-Postpone postpartum insertion and insertions following second trimester abortions a minimum of 6 weeks or until the uterus is fully involuted; if involution is delayed, wait until it is complete before insertion.
-If not inserted during first 7 days of menstrual cycle, abstinence or a barrier method should be used for 7 days following insertion; if using continuous hormonal contraception, discontinue method 7 days after IUS insertion.
-IUS should be replaced after 5 years [Mirena(R)] or 3 years [Skyla(R) and Liletta(R)] if continued use is desired.

Uses:
-Liletta(R) and Skyla(R): Prevention of pregnancy for up to 3 years
-Mirena(R): Prevention of pregnancy for up to 5 years in women who have had at least 1 child; Treatment of heavy menstrual bleeding

Emergency Contraception:
-One tablet of 1.5 mg orally once or two tablets of 0.75 mg orally, taken 12 hours apart

Comments:
-Doses should be taken as soon as possible within 72 hours after unprotected intercourse or known/suspected contraception failure.
-If vomiting occurs within 2 hours of taking either dose, consider repeating the dose.
-Efficacy is optimal if taken as soon as possible following unprotected intercourse.
-May be used at any time during the menstrual cycle; not intended for use in premenarcheal population.

Use: Prevention of pregnancy following unprotected intercourse or a known/suspected contraceptive failure

Usual Pediatric Dose for Contraception

Postpubertal adolescents less than 17 years and older:
Intrauterine System (IUS):
-Insert 1 IUS (13.5 mg or 52 mg) during the first 7 days of the menstrual cycle or immediately after a first trimester miscarriage or abortion
-Duration of therapy: Mirena(R): 5 years; Liletta(R) and Skyla(R): 3 years

Comments:
-Postpone postpartum insertion and insertions following second trimester abortions a minimum of 6 weeks or until the uterus is fully involuted; if involution is delayed, wait until it is complete before insertion.
-If not inserted during first 7 days of menstrual cycle, abstinence or a barrier method should be used for 7 days following insertion; if using continuous hormonal contraception, discontinue method 7 days after IUS insertion.
-IUS should be replaced after 5 years [Mirena(R)] or 3 years [Skyla(R) and Liletta(R)] if continued use is desired.
-Not intended for use in premenarcheal population.
Uses:
-Liletta(R) and Skyla(R): Prevention of pregnancy for up to 3 years
-Mirena(R): Prevention of pregnancy for up to 5 years in women who have had at least 1 child; Treatment of heavy menstrual bleeding

Emergency Contraception:
-One tablet of 1.5 mg orally once or two tablets of 0.75 mg orally, taken 12 hours apart

Comments:
-Doses should be taken as soon as possible within 72 hours after unprotected intercourse or known/suspected contraception failure.
-If vomiting occurs within 2 hours of taking either dose, consider repeating the dose.
-May be used at any time during the menstrual cycle; not intended for use in premenarcheal population.

Use: Prevention of pregnancy following unprotected intercourse or a known/suspected contraceptive failure

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

IUS:
-Acute liver disease or liver tumor: Contraindicated

Precautions

Safety and efficacy have been established in female patients of reproductive age; use prior to menarche is not indicated.

This drug has not been studied in patients 65 or older and is currently not approved for use in this population or postmenopausal woman.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-IUS: Consult the manufacturer product information for recommended insertion and removal techniques.

Timing of IUS Removal:
-If pregnancy is desired, the IUS may be removed at any time.
-If pregnancy is not desired, the IUS may be removed at any time, however, an alternate contraception method should be started prior to removal.

Storage requirements:
-IUS: For single use only; store pouch in outer carton until use to protect from light.
Monitoring:
-IUS Follow-up: Re-examine patient 4 to 6 weeks following IUS insertion and once a year thereafter, or more frequently if clinically indicated.
-Emergency Contraception Follow-up: Physical or pelvic exam is recommended if there is any doubt concerning general health or pregnancy status of any woman after using this drug for postcoital contraception.

Patient advice:
-Counsel patient of risk of becoming pregnant if intercourse occurs in the week prior to IUS removal without use of a backup contraceptive method.
-Contact your doctor if you become pregnant due to the risk of ectopic pregnancy.
-Report any signs/symptoms of lower abdominal pain, long-lasting or heavy bleeding, painful intercourse, chills, or fever.
-Report severe pain or fever following IUS insertion due to the risk of infection.

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