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Lanthanum Carbonate Dosage

Applies to the following strength(s): 250 mg ; 500 mg ; 750 mg ; 1000 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hyperphosphatemia of Renal Failure

Initial dose: 1500 mg orally daily; take in divided doses with meals
Titrate in increments of 750 mg/day every 2 to 3 weeks until an acceptable serum phosphate level is reached
Maximum dose: 4500 mg/day

Comments: Most patients will require daily doses between 1500 and 3000 mg to reduce plasma phosphate levels to less than 6 mg/dL.

Use: To reduce serum phosphate levels in patients with end stage renal disease.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

This drug is indicated for patients undergoing hemodialysis or continuous ambulatory peritoneal dialysis; therefore, no dosage adjustment is recommended.

Other Comments

Administration advice:
-Take with or immediately after meals
-Tablets must be chewed completely before swallowing; may crush tablets prior to administration if needed
-Oral powder should be sprinkled on a small quantity of applesauce (or similar food) and consumed immediately; do not attempt to dissolve in liquid as powder is insoluble

General:
-Patients should adhere to recommended diets in order to control phosphate and fluid intake.
-Patients with poor dentition or those who have difficulty chewing tablets should use the oral powder to avoid the risk of serious gastrointestinal events.

Monitoring:
-Serum phosphate levels should be monitored as needed during dose titration and regularly thereafter.
-Thyroid stimulating hormone (TSH) levels should be checked in patients receiving thyroid hormone replacement.
-Hypocalcemia may develop in patients with renal dysfunction; periodic monitoring of serum calcium levels is recommended.
-Consider monitoring liver function in patients with marked reduction of bile flow.

Patient advice:
-Patients should be instructed as to proper way to take this medication to avoid risk of serious gastrointestinal adverse events.
-Gastrointestinal events are common with initiation of therapy; taking this medication with food will minimize events and with continued dosing they tend to lessen.
-Antacids, thyroid medications, and antibiotic medications may need to be taken 1 to 2 hours before or 2 to 4 hours after taking this medication; check with a health care professional for specific timing.
-Patients should let their physician know they are taking this drug prior to an abdominal X-ray.

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