Medically reviewed by Drugs.com. Last updated on Aug 15, 2023.
Confirmation of Hypogonadism Before Initiation of JATENZO
Prior to initiating JATENZO, confirm the diagnosis of hypogonadism by ensuring that serum testosterone concentrations have been measured in the morning on at least two separate days and that these testosterone concentrations are below the normal range.
Dosing and Dose Adjustment Information
Individualize the dosage of JATENZO based on the patient's serum testosterone concentration response to the drug. The recommended starting dose is 237 mg taken orally twice daily, once in the morning and once in the evening. Take JATENZO with food.
To ensure proper dose adjustment, measure serum testosterone concentrations 6 hours after the morning dose in plain tubes, clotted at room temperature for 30 minutes prior to centrifugation. Adjust the JATENZO dose based on this serum testosterone measurement as shown in Table 1. Wait seven days after starting treatment or adjusting the dose before checking the serum testosterone concentration. Thereafter, periodically monitor serum testosterone concentrations 6 hours after the morning dose.
Administer the same dose in the morning and evening. The minimum recommended dose is 158 mg twice daily. The maximum recommended dose is 396 mg (two 198 mg capsules) twice daily.
|Testosterone Concentration in Serum From Plain Tube Drawn 6 hours After Morning Dose||Current JATENZO Dose
(mg, twice daily)
|New JATENZO Dose
(mg, twice daily)
|Less than 425 ng/dL||158||198|
|237||316 (two 158 mg capsules)|
|316 (two 158 mg capsules)||396 (two 198 mg capsules)|
|425 ng/dL – 970 ng/dL||No Dose Change|
|More than 970 ng/dL
||396 (two 198 mg capsules)||316 (two 158 mg capsules)|
|316 (two 158 mg capsules)||237|
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