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Hydrochlorothiazide / Reserpine Dosage

Applies to the following strengths: 25 mg-0.125 mg; 50 mg-0.125 mg

Usual Adult Dose for Hypertension

Initial dose: 1 to 2 tablets (hydrochlorothiazide/reserpine 25 mg-0.125 mg) orally once a day or
1 tablet (hydrochlorothiazide/reserpine 50 mg-0.125 mg) orally once a day.
Should conform to the dosages of the individual components established during titration.

Renal Dose Adjustments

Hydrochlorothiazide is generally not effective in patients with creatine clearance less than 25 mL/min. Use hydrochlorothiazide with caution in patients with severe renal disease.

Liver Dose Adjustments

Use hydrochlorothiazide with caution in patients with impaired hepatic function.

Dose Adjustments

Patients usually do not require doses in excess of 50 mg of hydrochlorothiazide daily when combined with other antihypertensive agents. Dosage may require adjustment according to the blood pressure response of the patient. For maintenance, dosage should be adjusted to the lowest requirements of the individual patient.


Doses higher than 0.25 mg daily of reserpine should be used cautiously, because occurrence of serious mental depression and other side effects may increase considerably.


Reserpine is not dialyzable. The degree to which hydrochlorothiazide is removed by hemodialysis has not been established.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.