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Hydrochlorothiazide / Quinapril Dosage

Medically reviewed by Last updated on Feb 23, 2023.

Applies to the following strengths: 12.5 mg-20 mg; 12.5 mg-10 mg; 25 mg-20 mg

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Hydrochlorothiazide 12.5 to 25 mg-quinapril 10 to 20 mg orally once a day


  • The initial dosage of hydrochlorothiazide-quinapril should be based on the patient requirements for each drug individually.

Renal Dose Adjustments

CrCl less than 25 mL/min: Not recommended

Liver Dose Adjustments

Caution is recommended.



  • PREGNANCY: Drugs that act directly on the renin-angiotensin system (including ACE inhibitors) can cause injury and death to a developing fetus. Hydrochlorothiazide-quinapril should be discontinued immediately if pregnancy is detected.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Quinapril is not removed by hemodialysis or peritoneal dialysis.

Other Comments

  • Hydrochlorothiazide-quinapril should be administered at the same time each day without regard to food.
  • In patients with renal impairment requiring concomitant diuretic therapy, a loop diuretic is preferred over a thiazide diuretic.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.