Hydrochlorothiazide / Propranolol Dosage

Usual Adult Dose for Hypertension

Hydrochlorothiazide 12.5 to 25 mg-Propranolol 40 to 80 mg orally twice a day

Maximum dose: Hydrochlorothiazide 50 mg-Propranolol 160 mg per day

Comments: When necessary, another antihypertensive agent may be added gradually beginning with 50% of the usual recommended starting dose.

Renal Dose Adjustments

Use with caution

Liver Dose Adjustments

Use with caution

Precautions

US BOXED WARNING:

• DISCONTINUING THERAPY: There have been reports of exacerbation of angina and myocardial infarction following abrupt discontinuation of propranolol. Discontinue propranolol by gradually reducing the dose and carefully monitoring the patient. Patients should be cautioned against interruption or cessation of therapy without a physician's advice. If propranolol therapy is interrupted and angina exacerbation occurs, reinstitute propranolol therapy and take other measures appropriate for the management of unstable angina pectoris.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

General:

• Not indicated for initial treatment of hypertension.
• Dose selection for elderly patients should be cautious, usually starting at the low end of the dosing range.

Monitoring:

• Discontinuing therapy: Angina signs and symptoms
• Metabolic: Serum electrolytes periodically

Patient advice:

• Caution patients against interruption or cessation of therapy without a physician's advice.
• Inform patients that this drug may interfere with glaucoma screening tests as beta blockade can cause reduction of intraocular pressure.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer