Hydrochlorothiazide / Propranolol Dosage
Applies to the following strengths: 50 mg-80 mg; 50 mg-120 mg; 50 mg-160 mg; 25 mg-40 mg; 25 mg-80 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Hydrochlorothiazide 12.5 to 25 mg-Propranolol 40 to 80 mg orally twice a day
Maximum dose: Hydrochlorothiazide 50 mg-Propranolol 160 mg per day
Comments: When necessary, another antihypertensive agent may be added gradually beginning with 50% of the usual recommended starting dose.
Renal Dose Adjustments
Use with caution
Liver Dose Adjustments
Use with caution
US BOXED WARNING:
- DISCONTINUING THERAPY: There have been reports of exacerbation of angina and myocardial infarction following abrupt discontinuation of propranolol. Discontinue propranolol by gradually reducing the dose and carefully monitoring the patient. Patients should be cautioned against interruption or cessation of therapy without a physician's advice. If propranolol therapy is interrupted and angina exacerbation occurs, reinstitute propranolol therapy and take other measures appropriate for the management of unstable angina pectoris.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
- Not indicated for initial treatment of hypertension.
- Dose selection for elderly patients should be cautious, usually starting at the low end of the dosing range.
- Discontinuing therapy: Angina signs and symptoms
- Metabolic: Serum electrolytes periodically
- Caution patients against interruption or cessation of therapy without a physician's advice.
- Inform patients that this drug may interfere with glaucoma screening tests as beta blockade can cause reduction of intraocular pressure.
More about hydrochlorothiazide / propranolol
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- During pregnancy
- Drug class: beta blockers with thiazides
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